118672-28-9Relevant articles and documents
SYNTHESIS OF (E)-ALPHA, BETA UNSATURATED SULFIDES, SULFONES, SULFOXIDES AND SULFONAMIDES
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Page/Page column 43, (2008/06/13)
α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula (I): wherein Ar1, Ar2, X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy sulfides, sulfones, sulfoxides or sulfonamides.
(E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
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, (2008/06/13)
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a
Styryl sulfone anticancer agents
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, (2008/06/13)
Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have