118684-17-6

Basic information

• Product Name: Benzenamine, 3,5-dimethoxy-N-methyl-
• CAS NO: 118684-17-6
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Mol File: 118684-17-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenamine, 3,5-dimethoxy-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 3,5-dimethoxy-N-methyl-(118684-17-6)
• EPA Substance Registry System: Benzenamine, 3,5-dimethoxy-N-methyl-(118684-17-6)

Safety Data

• Hazardous Substances Data: 118684-17-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 10272-07-8 3.5-dimethoxyaniline 
• 50-00-0 formaldehyd 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 74-89-5 methylamine 
• 74-88-4 methyl iodide 

Downstream Products

• 1132660-78-6 4-{[(3,5-dimethoxyphenyl)(methyl)amino]carbonyl}phenyl acetate 
• 1132660-77-5 4-chloro-N-(3,5-dimethoxyphenyl)-N-methyl-3-nitrobenzamide 
• 132905-28-3 5,7-dimethoxy-4-(4-methoxyphenyl)-1-methyl-2-(1H)-quinolinone 

Relevant articles and documents

Additive-freeN-methylation of amines with methanol over supported iridium catalyst

An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-freeN-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOxand ZnO support also promoted its high reactivity. The selectivity of this catalyticN-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation ofN,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production ofN-methylated amines. With optimal flow rates and amine concentrations, a variety ofN-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production ofN-methylamines with this cost-effective chemical process.

Two consecutive palladium(II)-promoted C-H alkenylation reactions for the synthesis of 3-alkenylquinolones

Highly substituted quinolones are obtained through an efficient and atom economical procedure that involves two consecutive palladium(II)-catalyzed C-H alkenylation reactions. A selective 6-endo intramolecular C-H alkenylation leads to 4-substituted quinolones that have been further functionalized at C-3 through a second intermolecular C-H alkenylation reaction.

Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition

Tat (transactivator of transcription) is a small HIV protein rich in arginines that interacts with a viral RNA structure called TAR (trans-activation responsive region). Tat-TAR interaction is essential for viral gene expression, replication and pathogene