1187315-08-7Relevant articles and documents
Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells
Herfindal, Lars,Kasprzykowski, Franciszek,Schwede, Frank,?ankiewicz, Leszek,Fladmark, Kari E.,?ukomska, Joanna,Wahlsten, Matti,Sivonen, Kaarina,Grzonka, Zbigniew,Jastorff, Bernd,D?skeland, Stein Ove
experimental part, p. 5759 - 5762 (2010/03/24)
We report the esterification of the carboxyl groups of the cyclic peptide toxins nodularin-R and microcystin-LA to produce stable diacetoxymethyl and dipropionyloxymethyl ester derivatives. The derivatives had no activity but were reactivated upon esteras