118807-82-2

Basic information

• Product Name: (4-methoxy-2-nitro-phenylamino)-acetic acid ethyl ester
• Synonyms: (4-methoxy-2-nitro-phenylamino)-acetic acid ethyl ester
• CAS NO: 118807-82-2
• Molecular Weight: 254.243
• Mol File: 118807-82-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 76-78 °C(Solv: ethanol (64-17-5))
• Boiling Point: 399.4±37.0 °C(Predicted)
• Density: 1.285±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (4-methoxy-2-nitro-phenylamino)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxy-2-nitro-phenylamino)-acetic acid ethyl ester(118807-82-2)
• EPA Substance Registry System: (4-methoxy-2-nitro-phenylamino)-acetic acid ethyl ester(118807-82-2)

Safety Data

• Hazardous Substances Data: 118807-82-2(Hazardous Substances Data)

Usage

General Description

(4-methoxy-2-nitro-phenylamino)-acetic acid ethyl ester is a chemical compound that is commonly used in organic chemistry and pharmaceutical research. It is an ethyl ester derivative of (4-methoxy-2-nitro-phenylamino)-acetic acid, which has potential bioactivity and application in drug development. The compound contains a nitro group, a methoxy group, and an amino group, which makes it a versatile building block for the synthesis of various organic molecules. Its chemical structure and properties make it a valuable tool for researchers in understanding molecular interactions and in the development of new drugs with potential pharmacological uses.

Upstream product

• 105-36-2 ethyl bromoacetate 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 96-96-8 4-methoxy-2-nitroaniline 
• 577-72-0 4-methoxy-3-nitroaniline 
• 118807-88-8 2-((4-methoxy-2-nitrophenyl)amino)acetonitrile 
• 64-17-5 ethanol 
• 55687-28-0 (4-methoxy-2-nitrophenyl)glycine 

Downstream Products

• 55687-29-1 7-methoxy-3,4-dihydroquinoxalin-2(1H)-one 
• 1598416-94-4 1-(2-(4-(4-fluoro-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one 
• 1598417-00-5 7-methoxy-1-(2-(4-(4-methyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one 
• 1598417-01-6 1-(2-(7-methoxyquinoxalin-2-yloxy)ethyl)-N-(4-methyl-3-nitrobenzyl)piperidin-4-amine 
• 1598417-04-9 1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one 
• 1598417-05-0 7-methoxy-1-(2-(4-(3-methyl-4-nitrobenzylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one 
• 55687-28-0 (4-methoxy-2-nitrophenyl)glycine 
• 55687-30-4 7-methoxyquinoxalin-2(1H)-one 
• 118807-93-5 5-Methoxy-1H-benzoimidazole 3-oxide 

Relevant articles and documents

X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor

Small molecules that interact with the colchicine binding site in tubulin have demonstrated therapeutic efficacy in treating cancers. We report the design, syntheses, and antitumor efficacies of new analogues of pyridopyrimidine and hydroquinoxalinone compounds with improved drug-like characteristics. Eight analogues, 5j, 5k, 5l, 5m, 5n, 5r, 5t, and 5u, showed significant improvement in metabolic stability and demonstrated strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. We report crystal structures of tubulin in complex with five representative compounds, 5j, 5k, 5l, 5m, and 5t, providing direct confirmation for their binding to the colchicine site in tubulin. A quantitative structure-activity relationship analysis of the synthesized analogues showed strong ability to predict potency. In vivo, 5m (4 mg/kg) and 5t (5 mg/kg) significantly inhibited tumor growth as well as melanoma spontaneous metastasis into the lung and liver against a highly paclitaxel-resistant A375/TxR xenograft model.

Synthesis of [18F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones

A practical method for radiofluorination of anilines with [18F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18F-labeling to prepare [

Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: Broad-spectrum antibacterial agents with reduced hERG activity

Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new antibacterial agents that are not impacted by target-mediated cross-resistance with fluoroquinolones. Aminopiperidines that have a bicyclic aromatic moiety linked through a carbon to an ethyl bridge, such as 1, generally show potent broad-spectrum antibacterial activity, including quinolone-resistant isolates, but suffer from potent hERG inhibition (IC50= 3 M for 1). We now disclose the finding that new analogues of 1 with an N-linked cyclic amide moiety attached to the ethyl bridge, such as 24m, retain the broad-spectrum antibacterial activity of 1 but show significantly less hERG inhibition (IC 50= 31 M for 24m) and higher free fraction than 1. One optimized analogue, compound 24l, showed moderate clearance in the dog and promising efficacy against Staphylococcus aureus in a mouse thigh infection model.