1191078-74-6 Usage
Description
Amino-PEG5-acid is a PEG compound featuring an amino group with a terminal carboxylic acid group. This hydrophilic PEG spacer enhances solubility in aqueous media, while the amine group is reactive with carboxylic acids, activated NHS esters, and carbonyls (ketone, aldehyde). The terminal carboxylic acid can form a stable amide bond with primary amine groups in the presence of activators such as EDC or HATU.
Uses
Used in Pharmaceutical Industry:
Amino-PEG5-acid is used as a spacer for enhancing the solubility and stability of drug molecules. Its ability to form stable amide bonds with primary amine groups allows for the creation of prodrugs or drug conjugates with improved pharmacokinetic properties.
Used in Bioconjugation:
Amino-PEG5-acid is used as a linker for bioconjugation applications, facilitating the attachment of biologically active molecules, such as peptides, proteins, or nucleic acids, to various surfaces or other molecules. This enhances the stability and bioactivity of the conjugated species.
Used in Drug Delivery Systems:
Amino-PEG5-acid is used as a component in drug delivery systems, where it can act as a spacer to control the release of encapsulated drugs or to improve the targeting of drug carriers to specific cells or tissues.
Used in Diagnostic Imaging:
Amino-PEG5-acid is used as a spacer in the development of imaging agents, allowing for the attachment of contrast agents or targeting moieties to improve the specificity and sensitivity of diagnostic imaging techniques.
Used in Cosmetics and Personal Care:
Amino-PEG5-acid is used as a solubility enhancer and stabilizer in cosmetic and personal care products, improving the formulation and performance of various creams, lotions, and other topical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1191078-74-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,1,0,7 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1191078-74:
(9*1)+(8*1)+(7*9)+(6*1)+(5*0)+(4*7)+(3*8)+(2*7)+(1*4)=156
156 % 10 = 6
So 1191078-74-6 is a valid CAS Registry Number.
1191078-74-6Relevant articles and documents
Preparation method of amino polyethylene glycol propionic acid
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Paragraph 0095; 0101-0103, (2019/01/14)
The invention relates to the field of organic synthesis, in particular to a preparation method of amino polyethylene glycol propionic acid. The preparation method comprises the steps that catalytic hydrogenation is carried out on dibenzyl amino polyethylene glycol tert-butyl propionate shown in formula I-2 to obtain amino polyethylene glycol tert-butyl propionate shown in formula I-3; (2) the amino polyethylene glycol tert-butyl propionate shown in formula I-3 is hydrolyzed under the acidic condition to obtain amino polyethylene glycol propionic acid shown in formula I. The preparation methodof the amino polyethylene glycol propionic acid has the advantages that the defects in the prior art that the yield is low, the dangerousness is high, and the enlargement of production is difficult are overcome, the reaction conditions are mild, the operation is simple, an intermediate does not to be purified, the next reaction can be directly carried out, the whole yield reaches up to 87-92%, thepurity of end products reaches up to 97-99.5%, and a safe and efficient synthetic route is provided for the preparation of amino polyethylene glycol propionic acid.
