1192755-04-6Relevant articles and documents
Synthesis and anti-influenza a virus activity of 6′-amino-6′-deoxy-glucoglycerolipids analogs
Ren, Li,Zhang, Jun,Ma, Haizhen,Sun, Linlin,Zhang, Xiaoshuang,Yu, Guangli,Guan, Huashi,Wang, Wei,Li, Chunxia
, (2016/07/06)
A series of aminoglucoglycerolipids derivatives had been synthesized, including 6′-acylamido-glucoglycerolipids 1a-1f and corresponding 2′-acylamido-glucoglycerolipids 2a-2c bearing different fatty acids, glucosyl diglycerides 3a-3e bearing different func
Synthesis of glycoglycerolipid of 1,2-dipalmitoyl-3-(N-palmitoyl-6′- amino-6′-deoxy-α-D-glucosyl)-sn-glycerol and its analogues, inhibitors of human Myt1-kinase
Sun, Yihua,Zhang, Jun,Li, Chunxia,Guan, Huashi,Yu, Guangli
, p. 6 - 12 (2012/08/08)
A glycoglycerolipid 1a isolated from a marine alga showed inhibition to Myt1 kinase with IC50 of 0.12 μg/mL. We synthesized 1a and its seven analogues (1b-h) in an efficient method with high stereoselectivity. The process employed trichloroacetimidate donor 4b at low substrate concentration to achieve high α-selectivity (α/β = 33:1) in glycosylation reaction. The present synthesis provided various acyl derivatives required for the study on the structure-activity relationship later.