1193-21-1

Basic information

• Product Name: 4,6-Dichloropyrimidine
• Synonyms: IFLAB-BB F2124-0077;4,6-DICHLOROPYRIMIDINE;PYRIMIDINE, 4,6-DICHLORO-;4 6-DICHLOROPYRIMIDINE 99%;4,6-Dichoropyrimidine;Pyrimidine, 4,6-dichloro- (7CI,8CI,9CI);4,6-DIHYDROXY PYRIMIDINE 99+%;4,6-Dichloropyrimidine ,98%
• CAS NO: 1193-21-1
• Molecular Formula: C₄H₂Cl₂N₂
• Molecular Weight: 148.98
• EINECS: 214-770-2
• Product Categories: PYRIMIDINE;FINE Chemical & INTERMEDIATES;Halides;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;Nucleotides and Nucleosides;Pyrimidines;Bases & Related Reagents;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks;Heterocycle-Pyrimidine series;alkyl chloride
• Mol File: 1193-21-1.mol
• Article Data: 32

Chemical Properties

• Melting Point: 65-67 °C(lit.)
• Boiling Point: 176 °C(lit.)
• Flash Point: 176°C
• Appearance: Yellow-green/Crystals
• Density: 1.6445 (rough estimate)
• Vapor Pressure: 30-390Pa at 20-50℃
• Refractive Index: 1.6300 (estimate)
• Storage Temp.: -20°C
• Solubility: 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorl
• PKA: -4.20±0.17(Predicted)
• BRN: 111195
• CAS DataBase Reference: 4,6-Dichloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dichloropyrimidine(1193-21-1)
• EPA Substance Registry System: 4,6-Dichloropyrimidine(1193-21-1)

Safety Data

• Hazard Codes: C
• Statements: 34-20/21/22-36/37
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3263 8/PG 2
• WGK Germany: 3
• F: 19
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1193-21-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1193-21-1 differently. You can refer to the following data:
1. 4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.
2. 4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.

Chemical Properties

Yellow Solid

General Description

Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.

Synthesis

The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.

InChI:InChI:1S/C4H2Cl2N2/c5-3-1-4(6)8-2-7-3/h1-2H

Synthetic route

5-ethyl-2-methyl-pyridine (104-90-5) + 4,6-pyrimidinediol (1193-24-4) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
With trichlorophosphate	100%
With trichlorophosphate	98%

4,6-pyrimidinediol (1193-24-4) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
With triethylamine; trichlorophosphate at 40 - 105℃; for 2h;	99.1%
With chlorine; magnesium chloride; phosphorus trichloride In trichlorophosphate at 66℃; under 750.075 Torr; for 3.5h; Reagent/catalyst; Temperature; Pressure; Solvent;	99.83%
With bis(trichloromethyl) carbonate; sulfuric acid In N,N-dimethyl-formamide; 1,2-dichloro-benzene at 80℃; for 4.2h; Temperature; Solvent; Industrial scale;	97%

4,6-diaminopyrimidine (2434-56-2) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
Stage #1: 4,6-diaminopyrimidine With hydrogenchloride; sodium nitrite In water at -5℃; for 2h; Stage #2: With hydrogenchloride; copper(l) chloride In water at 45℃; for 2h;	86.4%

phosgene (75-44-5) + 4,6-pyrimidinediol (1193-24-4) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
With 2,3-Dimethylaniline In dichloromethane; water	80%
With N-ethyl-N,N-diisopropylamine In water; acetonitrile

4-chloro-6-methylsulfanylpyrimidine (89283-48-7) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
With sulfuryl dichloride In dichloromethane; acetonitrile at 0℃; for 0.5h;	76%

phosgene (75-44-5) + formamide (77287-34-4, 77287-35-5, 60100-09-6) + acetonitrile (75-05-8) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
at 20 - 140℃; under 982.607 - 20686.5 Torr; for 3h; the Parr Reactor (17328-33);	62.21%
at 105℃; under 5999.08 - 8378.02 Torr; for 3h;
With hydrogenchloride In chlorobenzene at 105℃; under 11739.6 Torr; for 23.5h;

1H-pyrimidine-4,6-dione (25286-58-2) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
With pyridine; trichlorophosphate
With N,N-dimethyl-aniline; trichlorophosphate

C6(2)H6*C4H2Cl2N2 → 4,6-dichloropyrimidine (1193-21-1) + benzene-d6 (1076-43-3)

Conditions	Yield
In tetrachloromethane at 34.9℃; Equilibrium constant;

acetamide (60-35-5) + phosgene (75-44-5) + formamide (77287-34-4, 77287-35-5, 60100-09-6) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
In chlorobenzene at 75 - 105℃; under 4913.04 - 17583.5 Torr; for 1.66667 - 23.1667h;

phosgene (75-44-5) + ethyl cyanoformate (623-49-4) + acetonitrile (75-05-8) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
With hydrogenchloride at 52 - 74℃;

phosgene (75-44-5) + aminoketone hydrochloride (25600-32-2) + acetamide hydrochloride (13507-15-8) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
In chlorobenzene at 105℃; under 14997.7 Torr; for 90h;

4-chloro-6-methoxy-pyrimidine (26452-81-3) → 4,6-dichloropyrimidine (1193-21-1)

phosgene (75-44-5) + 4,6-pyrimidinediol (1193-24-4) + Triphenylphosphine oxide (791-28-6) + dichlorotriphenylphosphorane (2526-64-9) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
In chlorobenzene

phosgene (75-44-5) + dmap (1122-58-3) + 4,6-pyrimidinediol (1193-24-4) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
In water; acetonitrile

1H-imidazole (288-32-4) + phosgene (75-44-5) + 4,6-pyrimidinediol (1193-24-4) → 4,6-dichloropyrimidine (1193-21-1)

Conditions	Yield
In acetonitrile

4,6-dichloropyrimidine (1193-21-1) + allylhydrazine (7422-78-8) → 4,6-bis[1-(prop-2-enyl)hydrazino]pyrimidine

Conditions	Yield
for 3h; Heating;	100%

4,6-dichloropyrimidine (1193-21-1) + methylhydrazine (60-34-4) → 4,6-bis(1-methylhydrazino)pyrimidine (618428-20-9)

Conditions	Yield
for 2h; Heating;	100%
for 2h; Inert atmosphere; Reflux;	86%
Reflux; Inert atmosphere;

4,6-dichloropyrimidine (1193-21-1) + dimethyl amine (124-40-3) → 6-chloro-N,N-dimethylpyrimidin-4-amine (31058-83-0)

Conditions	Yield
With triethylamine In isopropyl alcohol Heating;	100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 20℃; for 28h;
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;
With potassium carbonate In tetrahydrofuran; 1,4-dioxane for 14h; Reflux;
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethanol at 150℃; for 0.0833333h; Microwave irradiation;

4,6-dichloropyrimidine (1193-21-1) + tert-butyl [(3R)-pyrrolidin-3-yl]methylcarbamate (392338-15-7) → tert-butyl (R)-(1-(2-amino-6-chloropyrimidin-4-yl)pyrrolidin-3-yl)(methyl)carbamate (929716-71-2)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol for 24h; Product distribution / selectivity; Heating / reflux;	100%

(R)-4-[1-(4-fluorophenyl)ethyl]piperazine (862270-48-2) + 4,6-dichloropyrimidine (1193-21-1) → 4-chloro-6-{4-[(R)-1-(4-fluoro-phenyl)-ethyl]-piperazin-1-yl}-pyrimidine (1020064-27-0)

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 70℃; for 6h;	100%

4,6-dichloropyrimidine (1193-21-1) + tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (144222-22-0) → tert-butyl 4-((6-chloropyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate (939986-79-5)

Conditions	Yield
With potassium carbonate In acetonitrile at 120℃; for 0.5h; Microwave irradiation;	100%

4,6-dichloropyrimidine (1193-21-1) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate (442199-19-1)

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 60℃; for 1h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran; mineral oil at 20℃; for 2h;	100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 1h; Inert atmosphere; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃; for 2h;	72%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃;	59%

4,6-dichloropyrimidine (1193-21-1) + 4-carboxamidopiperidine (39546-32-2) → 1-(6-chloropyrimidin-4-yl)piperidine-4-carboxamide (1242240-92-1)

Conditions	Yield
With triethylamine In 1,4-dioxane at 100℃; for 1h; Inert atmosphere; Microwave irradiation;	100%
With triethylamine In ethanol at 100℃; for 1h; Microwave irradiation;	71%
With triethylamine Microwave irradiation;

4,6-dichloropyrimidine (1193-21-1) + 6-hydroxy-3,4-dimethyl-3H-benzoxazol-2-one (1231749-37-3) → 6-(6-chloro-pyrimidin-4-yloxy)-3,4-dimethyl-3H-benzoxazol-2-one (1231749-35-1)

Conditions	Yield
Stage #1: 6-hydroxy-3,4-dimethyl-3H-benzoxazol-2-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.166667h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;	100%

4,6-dichloropyrimidine (1193-21-1) + (S)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-6-ol (1231750-06-3) → (S)-6-(6-chloropyrimidin-4-yloxy)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazole (1231750-08-5)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	100%

4,6-dichloropyrimidine (1193-21-1) + 1-Boc-amine-11-amino-3,6,9-trioxaundecane (101187-40-0) → tert-butyl {2-[2-(2-{2-[(6-chloropyrimidin-4-yl)amino]ethoxy}ethoxy)ethoxy]ethyl}carbamate

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; for 17h;	100%

4,6-dichloropyrimidine (1193-21-1) + 2-(7-(difluoromethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-amine hydrochloride → 6-chloro-N-(2-(7-(difluoromethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)pyrimidin-4-amine

Conditions	Yield
With triethylamine In isopropyl alcohol at 95℃; for 2.5h; Inert atmosphere;	100%

4,6-dichloropyrimidine (1193-21-1) + (S)-1-(4-Fluoro-phenyl)-ethylamine (66399-30-2) → (S)-6-chloro-N-(1-(4-fluorophenyl)ethyl)pyrimidin-4-amine

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50℃; for 5h;	100%

4,6-dichloropyrimidine (1193-21-1) + (1S)-1-(2,4-difluorophenyl)ethanamine (845252-02-0) → C12H10ClF2N3

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50℃;	100%

4,6-dichloropyrimidine (1193-21-1) + 1-(2-chloro-4-fluorophenyl)ethan-1-amine → C12H10Cl2FN3

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50℃;	100%

4,6-dichloropyrimidine (1193-21-1) + 1,2-diamino-benzene (95-54-5) → C10H9ClN4

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 150℃; for 0.166667h; Irradiation;	100%

4,6-dichloropyrimidine (1193-21-1) + Sodium N-benzylglycinate → 6--4-chloropyrimidine (155670-20-5)

Conditions	Yield
In ethanol Heating;	99.2%

4,6-dichloropyrimidine (1193-21-1) + 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine (151266-23-8) → 1-(6-chloropyrimidin-4-yl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions	Yield
Stage #1: 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;	99.2%
Stage #1: 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;	99.2%
Stage #1: 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;	99.2%

4,6-dichloropyrimidine (1193-21-1) + (1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride (79200-57-0) → (1R,2S,3R,5R)-3-[(6-Chloropyrimidin-4-yl)amino]-5-(hydroxymethyl)-cyclopentane-1,2-diol (1007124-88-0)

Conditions	Yield
With triethylamine In isopropyl alcohol at 90℃; for 1h; Product distribution / selectivity;	99%
With triethylamine In ethanol at 150℃; for 0.25h; Product distribution / selectivity; Microwave irradiation;	90%

4,6-dichloropyrimidine (1193-21-1) + 3-Trifluoromethylphenol (98-17-9) → 4-chloro-6-[(α,α,α-trifluoro-m-tolyl)oxy]pyrimidine

Conditions	Yield
With potassium carbonate In acetone	99%
With potassium carbonate In acetone	99%

4,6-dichloropyrimidine (1193-21-1) + 4-fluoro-3-(trifluoromethyl)phenol (61721-07-1) → 4-chloro-6-[(α,α,α,4-tetrafluoro-m-tolyl)oxy]pyrimidine

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	99%
With potassium carbonate In N,N-dimethyl-formamide	99%
With potassium carbonate In N,N-dimethyl-formamide	99%
With sodium hydroxide In water; toluene	70%

4,6-dichloropyrimidine (1193-21-1) → 6-chloroisocytosine (1194-21-4)

Conditions	Yield
With acetic acid In sodium hydroxide	99%

4,6-dichloropyrimidine (1193-21-1) + isobutylamine (78-81-9) → 4-isobutylamino-6-chloropyrimidine (1220028-08-9)

Conditions	Yield
In methanol at 20℃; for 6.16667h; Cooling with ice;	99%

4,6-dichloropyrimidine (1193-21-1) + 4-Aminobiphenyl (92-67-1) → N-([1,1'-biphenyl]-4-yl)-6-chloropyrimidin-4-amine

Conditions	Yield
With triethylamine In ethanol at 120℃; for 3h;	99%

pyrrolidine (123-75-1) + 4,6-dichloropyrimidine (1193-21-1) → 4-Chloro-6-(pyrrolidin-1-yl)pyrimidine (939986-64-8)

Conditions	Yield
With triethylamine In isopropyl alcohol Heating;	98%
With triethylamine In ethanol at 20℃; for 0.25h;	63%
In isopropyl alcohol Reflux;

4,6-dichloropyrimidine (1193-21-1) + t-butoxycarbonylhydrazine (870-46-2) → tert-butyl N-[(6-chloropyrimidin-4-yl)amino]carbamate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran Reflux;	98%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 68h; Reflux;	98%
With N-ethyl-N,N-diisopropylamine In ethanol at 120℃; for 1h;

4,6-dichloropyrimidine (1193-21-1) + D-phenylalanine methyl ester hydrochloride (13033-84-6) → methyl (2R)-2-[(6-chloropyrimidin-4-yl)amino]-3-phenylpropanoate (693792-77-7)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 80℃;	98%

4,6-dichloropyrimidine (1193-21-1) + 6-(2-methyl-5-nitrophenyl)-1H-indole (1298084-34-0) → 1-(6-chloropyrimidine-4-yl)-6-(2-methyl-5-nitrophenyl)-1H-indole (1298084-35-1)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil	98%

Upstream product

• 1193-24-4 4,6-pyrimidinediol 
• 26452-81-3 4-chloro-6-methoxy-pyrimidine 
• 75-44-5 phosgene 
• 791-28-6 Triphenylphosphine oxide 
• 2526-64-9 dichlorotriphenylphosphorane 
• 104-90-5 5-ethyl-2-methyl-pyridine 
• 89283-48-7 4-chloro-6-methylsulfanylpyrimidine 
• 2434-56-2 4,6-diaminopyrimidine 
• 288-32-4 1H-imidazole 
• 623-49-4 ethyl cyanoformate 
• 75-05-8 acetonitrile 
• 60-35-5 acetamide 
• 77287-34-4 formamide 
• 25286-58-2 1H-pyrimidine-4,6-dione 

Downstream Products

• 54503-93-4 4-chloro-6-piperidin-1-yl-pyrimidine-5-carbaldehyde 
• 156592-09-5 4,6-diphenoxypyrimidine 
• 169677-46-7 4-tert-butyl-N-(6-chloro-4-pyrimidinyl)benzenesulfonamide 
• 36847-10-6 4,6-dibromopyrimidine 
• 263274-39-1 S-ethyl 3-[4-(3,5-dichloropyrid-4-ylcarboxamido)phenyl]-2-(6-chloropyrimidin-4-ylamino)propionate 
• 1450-90-4 4,6-bis(methylthio)pyrimidine 
• 263276-29-5 4-chloro-6-propylthio-pyrimidine 
• 3977-48-8 4,6-diphenylpyrimidine 
• 168915-00-2 4,6-bis(4-fluorophenyl)pyrimidine 
• 869639-13-4 4-chloro-6-(3,4-dimethoxyphenoxy)pyrimidine 
• 61667-11-6 4-chloro-6-cyclohexylaminopyrimidine 
• 124041-02-7 4-chloro-6-(4-chlorophenoxy)pyrimidine 
• 607723-54-6 4-chloro-6-(4-methoxyphenoxy)pyrimidine 
• 83774-13-4 4-chloro-6-isopropoxypyrimidine 

Relevant articles and documents

The efficient one-step chlorination of methylsulfanyl group on pyrimidine ring system with sulfuryl chloride

A facile one-step transformation of methylsulfanyl and arylsulfanyl groups on pyrimidine ring system into the corresponding chloride group was achieved using sulfuryl chloride in acetonitrile/dichloromethane.

Preparation method of 4, 6-dichloropyrimidine

The invention discloses a preparation method of 4, 6-dichloropyrimidine, which comprises the following steps: (1) dissolving 4, 6-dihydroxypyrimidine and a catalyst in a polar solvent, and mixing to obtain a mixed solution containing 4, 6-dihydroxypyrimidine; (2) adding chlorine or liquid chlorine into the mixed solution, and reacting to obtain a mixed solution containing 4, 6-dichloropyrimidine;(3) distilling the mixed solution containing 4, 6-dichloropyrimidine to remove the solvent, deacidifying, and distilling to recover byproduct phosphorus oxychloride, thereby obtaining a 4, 6-dichloropyrimidine crude product; (5) carrying out extraction separation on the 4, 6-dichloropyrimidine crude product, carrying out flash evaporation to remove a solvent and leave 4, 6-dichloropyrimidine in awater phase; and cooling and crystallizing the water phase, and carrying out dehydration treatment to obtain the 4, 6-dichloropyrimidine product. According to the method, the low-price easily-available catalyst is adopted, so that the reaction efficiency can be remarkably improved; chlorine/liquid chlorine is used as a chlorinating agent, so that the risk of the process is greatly reduced, and thebyproduct phosphorus oxychloride with high additional value is produced.

Synthesis process 4,6-dichloropyrimidine (by machine translation)

The invention provides a method 4,6 - for synthesizing,dichloropyrimidine as the raw material, with,hydroxypyrimidine as the reaction, 4,6 -dimethylaniline is used as the reaction, and the part of wastewater generated by,dimethylaniline in the finally produced wastewater N,N - according to the present invention is not limited to the consumption amount of the.dichloropyrimidine product produced by the invention, as a raw material. 4,6 - The present invention provides a method for producing waste water, by rectification in a manner of rectifying the product by distillation in a manner of rectifying, the product by a rectification method according to the present invention as a raw material solution, and a, solvent; in 1kg4,6 - a solvent; according to the present invention as a raw material of the present 6 - 7kg, invention in the present invention. (by machine translation)

Pyrimidine hydrazone derivative and preparation method and application thereof

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