119302-19-1 Usage
Description
(2a,3a,5a,16b,17b)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol is a complex organic compound belonging to the steroid family. It is characterized by its unique molecular structure, which includes an epoxy group at the 2,3-positions, a pyrrolidinyl group at the 16-position, and a hydroxyl group at the 17-position. (2a,3a,5a,16b,17b)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol is derived from androstanol, a naturally occurring steroid alcohol, and has been modified to possess specific functional groups that make it useful in various applications.
Uses
Used in Pharmaceutical Industry:
(2a,3a,5a,16b,17b)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol is used as an intermediate in the synthesis of rocuronium bromide (R639500), which is a neuromuscular blocking agent. (2a,3a,5a,16b,17b)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol plays a crucial role in the development of medications that are used during surgical procedures to facilitate muscle relaxation and ensure patient comfort.
Rocuronium bromide is particularly effective due to its rapid onset and short duration of action, making it a preferred choice for many anesthesiologists and surgeons. The compound (2a,3a,5a,16b,17b)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol is a key component in the production of this important drug, contributing to its overall effectiveness and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 119302-19-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,3,0 and 2 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 119302-19:
(8*1)+(7*1)+(6*9)+(5*3)+(4*0)+(3*2)+(2*1)+(1*9)=101
101 % 10 = 1
So 119302-19-1 is a valid CAS Registry Number.
InChI:InChI=1/C23H37NO2/c1-22-8-7-16-15(6-5-14-11-19-20(26-19)13-23(14,16)2)17(22)12-18(21(22)25)24-9-3-4-10-24/h14-21,25H,3-13H2,1-2H3/t14-,15+,16-,17-,18-,19-,20+,21-,22-,23-/m0/s1
119302-19-1Relevant articles and documents
Processes for the synthesis of rocuronium bromide
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Page/Page column 17, (2008/06/13)
The invention encompasses processes for synthesizing 1-[17β-acetyloxy-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide (rocuronium bromide) and intermediates thereof.
Androstane derivatives substituted by a quaternary ammonium group in 16-position, pharmaceutical compositions containing them and process for preparing same
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, (2008/06/13)
There is disclosed novel, therapeutically active androstane derivatives having neuromuscular blocking effect, which are substituted by a quaternary ammonium group in 16-position; pharmaceutically composition containing them; process for producing them; and novel intermediates for the production.
