1193340-93-0

Basic information

• Product Name: methyl (E)-4-(benzyloxy)-6-(2-carboxyvinyl)-1,3-benzodioxole-5-carboxylate
• Synonyms: methyl (E)-4-(benzyloxy)-6-(2-carboxyvinyl)-1,3-benzodioxole-5-carboxylate
• CAS NO: 1193340-93-0
• Molecular Weight: 356.332
• Mol File: 1193340-93-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (E)-4-(benzyloxy)-6-(2-carboxyvinyl)-1,3-benzodioxole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-4-(benzyloxy)-6-(2-carboxyvinyl)-1,3-benzodioxole-5-carboxylate(1193340-93-0)
• EPA Substance Registry System: methyl (E)-4-(benzyloxy)-6-(2-carboxyvinyl)-1,3-benzodioxole-5-carboxylate(1193340-93-0)

Safety Data

• Hazardous Substances Data: 1193340-93-0(Hazardous Substances Data)

Upstream product

• 79-10-7 acrylic acid 

Downstream Products

• 1193340-94-1 methyl (E)-4-(benzyloxy)-6-(3-hydroxyprop-1-enyl)-1,3-benzodioxole-5-carboxylate 

Relevant articles and documents

Convergent synthesis of pancratistatin from piperonal and xylose

A synthesis of the antitumour agent pancratistatin is described from piperonal and D-xylose. Piperonal is converted into cinnamyl bromide 11 while methyl 5-iodoribofuranoside 12 is derived from xylose, The allylic bromide and the iodocarbohydrate are combined in a zinc-mediated tandem reaction to afford a highly functionalised 1,7-diene, which is then converted into the corresponding cyclohexene by ring-closing olefin metathesis. Subsequent Overman rearrangement, dihydroxylation and deprotection afford the natural product in a total of 25 steps from, the two starting materials. The longest linear sequence is from piperonal and gives rise to pancratistatin in 18 steps and 7.0% overall yield. Wiley-VCH Verlag GmbH & Co. KGaA.