119347-14-7 Usage
Description
2-Deacetoxytaxinine J is a chemical compound belonging to the taxinine family, characterized by its potential anti-tumor and anti-cancer properties. It is known for its ability to inhibit the growth and proliferation of cancer cells by disrupting microtubule assembly and function, thereby inducing cell cycle arrest and apoptosis in various cancer cell lines.
Uses
Used in Pharmaceutical Industry:
2-Deacetoxytaxinine J is used as a potential anti-cancer agent for its ability to inhibit the growth and proliferation of cancer cells. It is particularly effective in inducing cell cycle arrest and apoptosis, making it a promising candidate for the development of new anti-cancer drugs.
2-Deacetoxytaxinine J is used as a research compound for further investigation into its mechanism of action and potential therapeutic applications in the treatment of various cancer types. Its effectiveness in disrupting microtubule assembly and function suggests that it may be a valuable tool in the development of targeted cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 119347-14-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,3,4 and 7 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 119347-14:
(8*1)+(7*1)+(6*9)+(5*3)+(4*4)+(3*7)+(2*1)+(1*4)=127
127 % 10 = 7
So 119347-14-7 is a valid CAS Registry Number.
119347-14-7Relevant articles and documents
Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J
Botta, Maurizio,Armaroli, Silvia,Castagnolo, Daniele,Fontana, Gabriele,Pera, Paula,Bombardelli, Ezio
, p. 1579 - 1583 (2007/10/03)
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination
Studies on the Himalayan yew Taxus wallichiana: Part III - First report on isolation of a basic taxane
Chattopadhyay,Kulshrestha,Saha,Sharma,Kumar, Sushil
, p. 508 - 509 (2007/10/03)
The basic taxane 2′-deacetoxyaustrospicatine (1) has been isolated from the stem bark and needles of Taxus wallichiana, and converted into 2-deacetoxytaxinine J (2) through chemical reactions. This is the first report on the isolation of a basic taxane from the Himalayan yew.
PLANTES DE NOUVELLE-CALEDONIE. 114. TAXANES ISOLES DES FEUILLES D'AUSTROTAXUS SPICATA COMPTON (TAXACEES)
Ettouati, Laurent,Ahond, Alain,Convert, Odile,Laurent, Dominique,Poupat, Christiane,Potier, Pierre
, p. 749 - 755 (2007/10/02)
Seventeen compounds have been isolated from the leaves of Austrotaxus spicata: anemonine, usually extracted only from Renonculaceae, is the main product; the other have a taxane skeleton.Fourteen are alkaloidal and new; among these, twelve are described h
