119401-13-7 Usage
General Description
6-chloro-4-(2-fluorophenyl)-2-methylquinazoline is a chemical compound that belongs to the quinazoline family. It is a synthetic organic compound with a molecular formula C16H11ClFN3 and a molecular weight of 293.73 g/mol. 6-chloro-4-(2-fluorophenyl)-2-methylquinazoline is commonly used in medicinal chemistry and drug development as a starting material for the synthesis of various pharmaceutical drugs and biologically active molecules. It exhibits pharmacological properties that make it a potential candidate for the treatment of various diseases, including cancer and neurological disorders. Its chemical structure consists of a quinazoline core with a chlorine atom at the 6-position, a fluorine atom at the 2-position of the phenyl group, and a methyl group at the 2-position of the quinazoline ring.
Check Digit Verification of cas no
The CAS Registry Mumber 119401-13-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,4,0 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 119401-13:
(8*1)+(7*1)+(6*9)+(5*4)+(4*0)+(3*1)+(2*1)+(1*3)=97
97 % 10 = 7
So 119401-13-7 is a valid CAS Registry Number.
119401-13-7Relevant articles and documents
Lewis-Acid-Catalysed Activation of Nitriles: A Microwave-Assisted Solvent-Free Synthesis of 2,4-Disubstituted Quinazolines and 1,3-Diazaspiro[5.5]undec-1-enes
Saikia, Ujwal Pratim,Borah, Geetika,Pahari, Pallab
, p. 1211 - 1217 (2018)
Two different modes of cyclization take place to synthesize quinazoline, quinazolinone, and 1,3-diazaspiro[5.5]undec-1-ene derivatives through the Lewis-acid-catalysed activation of both aliphatic and aromatic nitriles in a single-step, solvent-free, and transition-metal-free reaction. An amidine is expected to form as an intermediate; this then undergoes intramolecular cyclization in a one-pot reaction sequence. The reaction is carried out under microwave irradiation using trimethylsilyltrifluoromethane sulfonate (TMSOTf) as a catalyst and nitriles as a nitrogen source with the respective reaction partners.
