1194098-48-0Relevant articles and documents
Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists
Chu, Guo-Hua,Saeui, Christopher T.,Worm, Karin,Weaver, Damian G.,Goodman, Allan J.,Broadrup, Robert L.,Cassel, Joel A.,DeHaven, Robert N.,LaBuda, Christopher J.,Koblish, Michael,Brogdon, Bernice,Smith, Steve,Bourdonnec, Bertrand Le,Dolle, Roland E.
scheme or table, p. 5931 - 5935 (2010/07/07)
Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a rat model of neuropathic pain.
