1194821-23-2

Basic information

• Product Name: ethyl 2-(2-(phenylamino)phenyl)acetate
• Synonyms: ethyl 2-(2-(phenylamino)phenyl)acetate
• CAS NO: 1194821-23-2
• Molecular Weight: 255.316
• Mol File: 1194821-23-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2-(phenylamino)phenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-(phenylamino)phenyl)acetate(1194821-23-2)
• EPA Substance Registry System: ethyl 2-(2-(phenylamino)phenyl)acetate(1194821-23-2)

Safety Data

• Hazardous Substances Data: 1194821-23-2(Hazardous Substances Data)

Upstream product

• 91-40-7 2-(phenylamino)benzoic acid 
• 62-53-3 aniline 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 2973-50-4 2-aminophenylacetonitrile 
• 64-17-5 ethanol 
• 1446358-11-7 2-(2-(phenylamino)phenyl)acetonitrile 
• 1446358-09-3 N-(2-(chloromethyl)phenyl)benzenamine 
• 53044-24-9 N-Phenyl-o-(hydroxymethyl)aniline 
• 23868-11-3 ethyl 2-(phenylamino)benzoate 

Downstream Products

• 494-19-9 9,10-dihydrodibenzazepine 
• 1446358-16-2 1-(2-(N-phenyl-N-tosylamino)phenyl)-2-methylpropan-2-ol 
• 1446358-17-3 3-(2-(N-phenyl-N-tosylamino)benzyl)pentan-3-ol 
• 1446358-18-4 2-(2-(N-phenyl-N-tosylamino)phenyl)-1,1-diphenylethanol 
• 1446358-22-0 2-(2-(N-phenyl-N-tosylamino)phenyl)acetic acid 
• 21737-58-6 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one 
• 1446358-27-5 11,11-diphenyl-10,11-dihydro-5H-dibenzo[b,f]azepine 
• 1446358-14-0 ethyl 2-(2-(N-phenyl-N-tosylamino)phenyl)acetate 

Relevant articles and documents

Friedel-crafts chemistry. Part 39. unprecedented facile route to the synthesis of benzo[b][1]benzazepines via intramolecular friedel-crafts cyclialkylations

A series of six pharmaceutically promising 5,6-dihydro-11H-benzo[b][1] benzazepine derivatives (1c-h) were cleanly prepared by Friedel-Crafts cyclialkylations of nitrogen-containing alkanols in the presence of AlCl3, 85% H2SO4 or polyphosphoric acid catalysts. The precursor alkanols (13a-f) were readily prepared by reaction of two synthesized carboxylic acid esters (12a, b) with different Grignard reagents. Also, two dibenzo[b,f]azepinones (15a, b) were prepared by Friedel-Crafts cycliacylation and reduced to the corresponding 5,6-dihydro-11H-benzo[b][1]benzazepines (1a, b). Overall, this approach allows easy and efficient access to polytricyclic amines from easily synthesized alkanols or cycloketones. A plausible carbocation mechanism is proposed to account for the results.