119484-03-6Relevant articles and documents
2-CYANOETHYL NUCLEOSIDE 3'-PHOSPHONATES AS NOVEL STARTING MATERIALS FOR OLIGONUCLEOTIDE SYNTHESIS
Wada, Takeshi,Hotoda, Hitoshi,Sekine, Mitsuo,Hata, Tsujiaki
, p. 4143 - 4146 (1988)
Various disubstituted phosphonates including alkylnucleoside 3'-phosphonates were converted rapidly into the corresponding phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichlorophosphorane (BDCP) as a chlorinating reagent.The reaction was found to be applicable to the rapid and practical synthesis of oligonucleotides.