119646-48-9

Basic information

• Product Name: 4-(HYDROXYMETHYL)PYRIDINE-2-CARBOXAMIDE
• Synonyms: 4-(HYDROXYMETHYL)PYRIDINE-2-CARBOXAMIDE;2-Pyridinecarboxamide,4-(hydroxymethyl)-(9CI)
• CAS NO: 119646-48-9
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15
• Product Categories: AMIDE
• Mol File: 119646-48-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 388.4±32.0 °C(Predicted)
• Appearance: /
• Density: 1.321±0.06 g/cm3(Predicted)
• PKA: 13.25±0.10(Predicted)
• CAS DataBase Reference: 4-(HYDROXYMETHYL)PYRIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(HYDROXYMETHYL)PYRIDINE-2-CARBOXAMIDE(119646-48-9)
• EPA Substance Registry System: 4-(HYDROXYMETHYL)PYRIDINE-2-CARBOXAMIDE(119646-48-9)

Safety Data

• Hazardous Substances Data: 119646-48-9(Hazardous Substances Data)

Usage

General Description

4-(Hydroxymethyl)pyridine-2-carboxamide is a chemical compound with the molecular formula C7H8N2O2. It is a derivative of pyridine and carboxamide, and it is commonly used as a building block in the synthesis of pharmaceuticals and fine chemicals. 4-(HYDROXYMETHYL)PYRIDINE-2-CARBOXAMIDE is known for its ability to act as a ligand in coordination complexes and as a precursor in the synthesis of various heterocyclic compounds. Additionally, 4-(Hydroxymethyl)pyridine-2-carboxamide has shown potential as a chelating agent and has been studied for its antimicrobial and antiparasitic properties. Overall, this chemical exhibits versatile reactivity and has various potential applications in medicinal chemistry and material science.

Upstream product

• 1452-77-3 pyridine-2-carboxylic acid amide 
• 67-56-1 methanol 
• 923169-37-3 4-(hydroxymethyl)pyridine-2-carboxylic acid 
• 117423-43-5 2-cyano-4-[{(tert-butyldimethylsilyl)oxy}methyl]pyridine 
• 586-95-8 pyridine-4-methanol 
• 117423-41-3 4-((tert-butyldimethylsilyloxy)methyl)pyridine 
• 77287-34-4 formamide 
• 71935-32-5 2-Cyano-4-(hydroxymethyl)pyridine 
• 166766-77-4 4-ethoxycarbonyl-2-pyridinecarboxamide 

Downstream Products

• 105250-17-7 2-amino-4-hydroxymethylpyridine 

Relevant articles and documents

Photochemical Alkylation, Hydroxyalkylation, and Alkoxylation of Pyridinecarboxamides in Alcohol

The UV-irradiation of 2- and 4-pyridinecarboxamides in alcohol brings about alkylation and/or hydroxyalkylation in the pyridine ring.In the irradiation of 3-pyridinecarboxamide in the presence of sulfuric acid, ionic reaction (alkoxylation at the 2- and 6-position) and radical reaction (alkylation at the 4- and 6-position) occur in parallel.The effects of quenchers indicate that two alkylation products originate from one excited triplet state which is quenched by energy-transfer mechanism and that two alkoxylation products originate from the excited singlet state.

Method for synthesizing 2-aminopyridine-4-methanol

The invention discloses a method for synthesizing 2-aminopyridine-4-methanol. The method comprises the following steps that 4-pyridylcarbinol reacts with an aqueous formamide solution to prepare a second compound; the second compound and a NaOH solution are mixed and placed into a reaction still, the temperature is controlled within 5-10 DEG C, a NaBrO solution is added dropwise into the reactionstill, after the dropwise addition is completed, the reaction is continuously conducted for 1-2 hours at the temperature, then the temperature is raised to 50-60 DEG C to enable the reaction to be conducted continuously for 1 hour and then reduced to room temperature, ethyl acetate is used for carrying out extraction several times, organic phases are combined, distillation under reduced pressure is conducted to remove ethyl acetate, and 2-aminopyridine-4-methanol is prepared. The synthesis method has the advantages that the operation is simple, the conditions are mild, few byproducts are generated, and the product purity and yield are high.

2-AMINOARYLCARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS

A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents (see structures) wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.