1198186-42-3Relevant articles and documents
Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins
Sindhikara, Dan,Wagner, Michael,Gkeka, Paraskevi,Güssregen, Stefan,Tiwari, Garima,Hessler, Gerhard,Yapici, Engin,Li, Ziyu,Evers, Andreas
supporting information, p. 12100 - 12115 (2020/11/02)
Macrocycles and cyclic peptides are increasingly attractive therapeutic modalities as they often have improved affinity, are able to bind to extended protein surfaces, and otherwise have favorable properties. Macrocyclization of a known binder may stabili