119841-74-6

Basic information

• Product Name: Benzenecarboximidoyl chloride, N,2-dihydroxy-
• Synonyms: N,2-dihydroxybenzenecarboximidoyl chloride;Benzenecarboximidoyl chloride,N,2-dihydroxy;N,2-dihydroxybenzimidoyl chloride
• CAS NO: 119841-74-6
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Mol File: 119841-74-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzenecarboximidoyl chloride, N,2-dihydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidoyl chloride, N,2-dihydroxy-(119841-74-6)
• EPA Substance Registry System: Benzenecarboximidoyl chloride, N,2-dihydroxy-(119841-74-6)

Safety Data

• Hazardous Substances Data: 119841-74-6(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 94-67-7 salicylaldehyde-oxime 

Downstream Products

• 1235471-24-5 4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 4-(sec-butyl)phenylamide 
• 712347-85-8 4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylic acid 
• 165532-43-4 ethyl 4,5-dihydro-3-(2-hydroxyphenyl)isoxazole-5-carboxylate 
• 16263-52-8 3-chlorobenzisoxazole 
• 1246465-41-7 5-(3-(2-hydroxyphenyl)isoxazol-5-yl)-N-phenylpentanamide 
• 597553-45-2 ethyl 3-(2-hydroxyphenyl)-6-methyl-4-oxo-4,5,6,7-tetrahydrobenzo[d]isoxazole-5-carboxylate 
• 120559-26-4 Acetic acid 2-(4-phenyl-isoxazol-3-yl)-phenyl ester 
• 97904-75-1 isoflavanone 
• 574-12-9 isoflavone 
• 59564-29-3 3-(2-hydroxyphenyl)-4-phenylisoxazole 

Relevant articles and documents

Synthesis and molecular modeling studies of N-Hydroxyindazolecarboximidamides as novel indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme that is highly overexpressed in various cancer cells and antigen-presenting cells. It has emerged as an attractive therapeutic target for cancer immunotherapy, which has prompted high interest in the development of small-molecule inhibitors. To discover novel IDO1 inhibitors, we designed and synthesized a series of N-hydroxyindazolecarboximidamides. Among the compounds synthesized, compound 8a inhibited both tryptophan depletion and kynurenine production through the IDO1 enzyme. Molecular docking studies revealed that 8a binds to IDO1 with the same binding mode as the analog, epacadostat (INCB24360). Here, we report the synthesis and biological evaluation of these hydroxyindazolecarboximidamides and present the molecular docking study of 8a with IDO1.

Five-membered azole heterocyclic compound and its preparation method, pharmaceutical composition and use thereof

The present invention relates to a five-membered azole heterocycle compound represented by the following general formula (I), a preparation method of the five-membered azole heterocycle compound, a drug composition of the five-membered azole heterocycle compound, and a use of the five-membered azole heterocycle compound in preparation of drugs for prevention or treatment of TGR5-mediated diseases. The formula (I) is represented by the instruction.

Synthesis and biological activity of 3-substituted isoxazolecarboxamides

A series of novel 3-substituted isoxazolecarboxamides have been prepared. A key step was 1,3-dipolar cycloaddition of nitrile oxides to α,β-unsaturated esters. Some of these compounds exhibited high fungicidal activities against Alternaria alternata, Botrytis cinerea, Rhizoctonia solani, Fusarium culmorum, and Phytophthora cactorum.