119942-99-3 Usage
Description
Phosphoramidon, with the chemical formula N-(α-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp, is a naturally occurring competitive inhibitor produced by Streptomyces tanashiensis. It is known for its ability to inhibit several soluble zinc metalloproteases, including neutral endopeptidase 24.11 (NEP), neprilysin, and endothelin-converting enzyme.
Uses
Used in Pharmaceutical Industry:
Phosphoramidon is used as an endothelin-converting enzyme inhibitor for attenuating lipopolysaccharide-induced acute lung injury. Its ability to inhibit this enzyme plays a crucial role in managing lung inflammation and injury.
Used in Enzyme Inhibition:
Phosphoramidon is used as a membrane metallo-endopeptidase inhibitor, specifically inhibiting the enzyme thermolysin. This application is essential in various research and therapeutic contexts where the inhibition of specific metalloproteases is required.
Used in Research and Development:
Phosphoramidon is used as a research tool for studying the functions and roles of NEP 24.11 and NEP2 in various biological processes. Its high specificity and potency make it a valuable compound for investigating the mechanisms of these enzymes and their potential as therapeutic targets.
Used in Alzheimer's Disease Research:
Phosphoramidon is used to induce a dramatic increase in amyloid-beta levels in rodents, which is crucial for understanding the pathogenesis of Alzheimer's disease and the development of potential treatments targeting amyloid-beta metabolism.
Biochem/physiol Actions
Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.
References
1) Stephenson and Kenny et al. (1987),?The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J.,?243?183.
2) Rose?et al.?(2002),?Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J.,?363?697
3) Ahn?et al.?(1998),?Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys.,?359?258
4) Marr and Hafez (2014),?Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci.,?6?187
Check Digit Verification of cas no
The CAS Registry Mumber 119942-99-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,9,4 and 2 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 119942-99:
(8*1)+(7*1)+(6*9)+(5*9)+(4*4)+(3*2)+(2*9)+(1*9)=163
163 % 10 = 3
So 119942-99-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H34N3O10P.Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34);