1200129-86-7Relevant articles and documents
Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1
Gazzard, Lewis,Appleton, Brent,Chapman, Kerry,Chen, Huifen,Clark, Kevin,Drobnick, Joy,Goodacre, Simon,Halladay, Jason,Lyssikatos, Joseph,Schmidt, Stephen,Sideris, Steve,Wiesmann, Christian,Williams, Karen,Wu, Ping,Yen, Ivana,Malek, Shiva
, p. 5704 - 5709 (2015/01/08)
Checkpoint kinase 1 (ChK1) is activated in response to DNA damage, acting to temporarily block cell cycle progression and allow for DNA repair. It is envisaged that inhibition of ChK1 will sensitize tumor cells to treatment with DNA-damaging therapies, an