120060-81-3Relevant articles and documents
Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives
Maestro, Aitor,Martín-Encinas, Endika,Alonso, Concepción,Martinez de Marigorta, Edorta,Rubiales, Gloria,Vicario, Javier,Palacios, Francisco
, p. 874 - 883 (2018/09/29)
An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma).
Application of silicon-phosphorus based reagents in synthesis of aminophosphonates. Part 2: Reactions of N-(Triphenylmethyl)-aldimines with the silylated phosphorus acid esters
Boduszek,Soroka
, p. 1105 - 1111 (2007/10/03)
Reactions of silylated phosphorus acid esters with N-triphenylmethylaldimines (N-tritylaldimines) were investigated. N-Tritylmethaneimine reacts at room temperature with a mixture of P(OMe)3 and Me3SiBr forming the corresponding aminophosphonate derivatives in high yield. Other N-tritylimines are resistant toward the silylated reagents at room temperature, but undergo a similar phosphorylation reaction at elevated temperatures to form the expected aminophosphonic acids.
PHOSPHONODIPEPTIDES. SYNTHESIS BY HOBt/DCC METHOD, MASS SPECTRA OF THE PROTECTED AND 1H NMR OF THE UNPROTECTED PHOSPHONODIPEPTIDES
Hermann, Petr,Lukes, Ivan,Maca, Bohumil,Budesinsky, Milos
, p. 43 - 54 (2007/10/02)
Phosphonodipeptides containing aminomethylphosphonic and 1-aminoethylphosphonic acids were synthesized by the active ester method using N-hydroxybenztriazole and DCC.Fragmentation in electron ionization mass spectra (EI/MS) of protected phosphonodipeptide
