120106-66-3

Basic information

• Product Name: 4,5-bis(4-chlorophenyl)-2H-1,2,3-triazole
• Synonyms: 4,5-bis(4-chlorophenyl)-2H-1,2,3-triazole
• CAS NO: 120106-66-3
• Molecular Weight: 290.152
• Mol File: 120106-66-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4,5-bis(4-chlorophenyl)-2H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-bis(4-chlorophenyl)-2H-1,2,3-triazole(120106-66-3)
• EPA Substance Registry System: 4,5-bis(4-chlorophenyl)-2H-1,2,3-triazole(120106-66-3)

Safety Data

• Hazardous Substances Data: 120106-66-3(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 19277-54-4 p-chlorophenyldiazomethane 
• 3510-48-3 4-chlorobenzaldehyde azine 
• 40739-81-9 (E)-4-methyl-N'-(4-methylbenzylidene)benzenesulfonohydrazide 
• 100-42-5 styrene 
• 873-32-5 2-Chlorobenzonitrile 
• 766-84-7 3-chloro-benzonitrile 
• 109-92-2 ethyl vinyl ether 
• 104-55-2 3-phenyl-propenal 
• 501-65-5 diphenyl acetylene 
• 104-88-1 4-chlorobenzaldehyde 
• 1820-42-4 bis(4-chlorophenyl)acetylene 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 

Downstream Products

• 1132647-59-6 C₂₅H₂₄Cl₂N₄O 
• 1132647-57-4 C₂₁H₂₀Cl₂N₄O 
• 1228505-61-0 C₂₂H₁₆Cl₂N₄O₂ 

Relevant articles and documents

Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles

Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t -BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H -1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.

1, 2, 3-TRIAZOLE DERIVATIVES AS NEW CANNABINOID-1 RECEPTOR ANTAGONISTS

The present invention relates to 1,2,3-triazole derivatives which can be used as cannabinoid CB1 receptor antagonists. In addition, the compound of the 1,2,3-triazole derivatives in the present invention can be formulated into a pharmaceutical composition

THE REACTIONS OF HYDRAZONES AND RELATED COMPOUNDS WITH STRONG BASES. PART 4. 4,5-DIARYL-1,2,3-TRIAZOLES FROM AROMATIC ALDEHYDE AZINES AND FROM THE REACTION OF ARENECARBONITRILES WITH ARYLDIAZOMETHANES

Reaction of aromatic aldehyde azines in dimethyl sulphoxide at 20 deg C with potassium t-butoxide gave 4,5-diaryl-1,2,3-triazoles (4) and stilbenes.Mechanisms were studied by addition of possible intermediates and by (14)C tracer methods.The synthesis of 4,5-diaryl-1,2,3-triazoles from arenecarbonitriles, aryldiazomethanes, and potassium t-butoxide in toluene is described and the mechanism is discussed.