1201633-86-4

Basic information

• Product Name: ethyl 2-(3-bromo-4-methylphenyl)acetate
• Synonyms: ethyl 2-(3-bromo-4-methylphenyl)acetate
• CAS NO: 1201633-86-4
• Molecular Weight: 257.127
• Mol File: 1201633-86-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(3-bromo-4-methylphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3-bromo-4-methylphenyl)acetate(1201633-86-4)
• EPA Substance Registry System: ethyl 2-(3-bromo-4-methylphenyl)acetate(1201633-86-4)

Safety Data

• Hazardous Substances Data: 1201633-86-4(Hazardous Substances Data)

Upstream product

• 26670-89-3 2-bromo-4-iodo-1-methylbenzene 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 1201633-89-7 C₁₃H₁₆BrNOS 
• 40180-80-1 3-bromo-4-methylacetophenone 
• 64-17-5 ethanol 
• 1201633-84-2 2-(3-bromo-4-methylphenyl)acetic acid 

Downstream Products

• 208989-24-6 1-bromo-2-(4-methyl-3-pentylphenyl)ethane 
• 1201633-85-3 2-(3-Bromo-4-methylphenyl)ethanol 
• 1201633-88-6 2-(4-methyl-3-pentylphenyl)ethanol 

Relevant articles and documents

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by ethyl 2-(4-bromo-2-chlorophenyl)acetate (3a), can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters.