1202160-36-8

Basic information

• Product Name: (R)-N-DeMethyl Dapoxetine
• Synonyms: (R)-N-DeMethyl Dapoxetine;(αR)-N-Methyl-α-[2-(1-naphthalenyloxy)ethyl]benzeneMethanaMine
• CAS NO: 1202160-36-8
• Molecular Formula: C₂₀H₂₁NO
• Molecular Weight: 291.38684
• Product Categories: Amines;Aromatics;Chiral Reagents;Metabolites & Impurities;Amines, Aromatics, Chiral Reagents, Metabolites & Impurities
• Mol File: 1202160-36-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 459.5±38.0 °C(Predicted)
• Appearance: /
• Density: 1.089±0.06 g/cm3(Predicted)
• PKA: 9.21±0.20(Predicted)
• CAS DataBase Reference: (R)-N-DeMethyl Dapoxetine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-DeMethyl Dapoxetine(1202160-36-8)
• EPA Substance Registry System: (R)-N-DeMethyl Dapoxetine(1202160-36-8)

Safety Data

• Hazardous Substances Data: 1202160-36-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1202160-36-8 differently. You can refer to the following data:
1. The (R)-metabolite of Dapoxetine (D185700). Selective serotonin reuptake inhibitor antidepressant
2. The (R)-metabolite of Dapoxetine (D185700). Selective serotonin reuptake inhibitor antidepressant.

Upstream product

• 90-15-3 α-naphthol 
• 1202160-34-6 (R)-3-methyl-4-phenyl-[1,2,3]oxathiazinane 2,2-dioxide 

Downstream Products

• 119357-36-7 (R)-N,N-dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine 

Relevant articles and documents

Highly efficient, enantioselective syntheses of (S)-(+)- and (R)-(-)-dapoxetine starting with 3-phenyl-1-propanol

(Chemical Equation Presented) A highly efficient, enantioselective sequence has been developed for the synthesis of (S)- and (R)-dapoxetine. The pathways involve the intermediacy of the 6-membered-ring sulfamate esters 4, which were generated by Du Bois asymmetric C-Hamination reactions of the prochiral sulfamate 3, catalyzed by the chiral dirhodium(II) complexes. During the course of our research, the absolute configuration of the enantiomer of 4-pheny[1,2,3]oxathiazinane 2,2-dioxide (4r), prepared by the Du Bois asymmetric C-H amination reaction of 3 and the Rh2(S-nap)4 catalyst, is determined to be R and not S as was originally reported.