1202243-06-8Relevant articles and documents
2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure-activity relationships
Gleave, Robert J.,Beswick, Paul J.,Brown, Andrew J.,Giblin, Gerard M.P.,Haslam, Carl P.,Livermore, David,Moses, Andrew,Nicholson, Neville H.,Page, Lee W.,Slingsby, Brian,Swarbrick, Martin E.
scheme or table, p. 6578 - 6581 (2010/06/12)
2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists.
