120226-55-3

Basic information

• Product Name: N-pivaloyl-p-chlorophenylmethylamine
• Synonyms: N-pivaloyl-p-chlorophenylmethylamine
• CAS NO: 120226-55-3
• Molecular Weight: 225.718
• Mol File: 120226-55-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-pivaloyl-p-chlorophenylmethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-pivaloyl-p-chlorophenylmethylamine(120226-55-3)
• EPA Substance Registry System: N-pivaloyl-p-chlorophenylmethylamine(120226-55-3)

Safety Data

• Hazardous Substances Data: 120226-55-3(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 104-86-9 4-chlorobenzylamine 
• 180143-66-2 2,2-Dimethyl-propionic acid 3-cyano-phenyl ester 
• 180143-65-1 4-cyanophenyl pivalate 
• 126980-33-4 4-chlorophenyl 2,2-dimethylpropionate 
• 72734-76-0 4-acetylphenyl pivalate 
• 4195-17-9 4-nitrophenyl pivalate 

Downstream Products

• 1224968-38-0 C₂₅H₂₆ClNO₂ 
• 1224968-37-9 C₂₀H₂₄ClNO₃ 
• 1522363-75-2 N-(4-chlorobenzyl)-3-hydroxy-2,2-dimethylpropanamide 
• 1522363-55-8 3-(4-chlorobenzylamino)-2,2-dimethyl-3-oxopropyl 2,2,2-trifluoroacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 120226-57-5 N-(4-Chloro-2-hydroxy-benzyl)-2,2-dimethyl-propionamide 
• 120226-56-4 5-Chloro-2-[(2,2-dimethyl-propionylamino)-methyl]-benzoic acid 

Relevant articles and documents

Palladium-Catalyzed β-Mesylation of Simple Amide via Primary sp3 C-H Activation

A β-mesylation of primary sp3 C-H bonds from simple amides with methanesulfonic anhydride (Ms2O) has been established successfully at 80 °C in a Pd(OAc)2 (catalyst)/K2S2O8 (oxidant)/CF3CH2OH (solvent) system. These amide substrates involve N-monosubstituted linear, branch, or cyclic alkanes, and electron-deficient benzyl compounds. The β-mesylated amide products can be converted easily to β-fluoroamides or β-lactams through inter- or intramolecular SN2 processes.

Kinetics and mechanism of aminolysis of phenyl acetates and phenyl trimethylacetates in dimethyl suldoxide

Kinetic studies have been carried out on the reactions of phenyl acetates and phenyl trimethylacetates in dimethyl sulfoxide.The rate ratios between the two acyl compounds, and the positive sign and large magnitude of the cross-interaction constants, ρXZ, between substituents X in the nucleophile and Z in the leaving group are considered to favour the rate-limiting expulsion of aryl oxide from the tetrahedral intermediate T+/-.The aprotic solvent used makes the proposed mechanism with a cyclic transition state more attractive especially in view of the greater charge dispersion and assistance to leaving group departure provided in such a structure.