1202580-59-3 Usage
Chemical structure
The compound consists of a triazole ring, an octanamide group, and a biphenyl-2-yl substituent linked to a 3-pyridinyl group.
Heterocyclic compound
It is a heterocyclic compound, which means it contains one or more rings of atoms with at least one heteroatom (an atom other than carbon).
Potential medicinal and biological properties
The compound has potential medicinal and biological properties, making it a candidate for further research and development in the pharmaceutical industry.
Research and pharmaceutical applications
It can be used in various research and pharmaceutical applications, such as drug discovery and development.
Specific chemical structure
The presence of a triazole ring, octanamide group, and biphenyl-2-yl and 3-pyridinyl substituents contribute to the compound's unique chemical structure and potential applications.
Functional groups
The compound contains several functional groups, including the triazole ring, amide group, and aromatic rings, which can participate in various chemical reactions and interactions.
Suitability for further investigation
The specific chemical structure and functional groups present in this compound make it suitable for further investigation and potential use in drug discovery and development.
Molecular weight
The molecular weight of the compound is approximately 398.47 g/mol.
Solubility
The solubility of the compound may vary depending on the solvent used, but it is likely to be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or methanol due to its nonpolar nature.
Check Digit Verification of cas no
The CAS Registry Mumber 1202580-59-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,2,5,8 and 0 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1202580-59:
(9*1)+(8*2)+(7*0)+(6*2)+(5*5)+(4*8)+(3*0)+(2*5)+(1*9)=113
113 % 10 = 3
So 1202580-59-3 is a valid CAS Registry Number.
1202580-59-3Relevant articles and documents
Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities
Bai, Jinhong,Liao, Chenzhong,Liu, Yanghan,Qin, Xiaochu,Chen, Jiaxuan,Qiu, Yatao,Qin, Dongguang,Li, Zheng,Tu, Zheng-Chao,Jiang, Sheng
, p. 5766 - 5779 (2016/07/06)
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) has the potential to directly limit NAD production in cancer cells and is an effective strategy for cancer treatment. Using a structure-based strategy, we have designed a new class of potent small-molecule inhibitors of NAMPT. Several designed compounds showed promising antiproliferative activities in vitro. (E)-N-(5-((4-(((2-(1H-Indol-3-yl)ethyl)(isopropyl)amino)methyl)phenyl)amino)pentyl)-3-(pyridin-3-yl)acrylamide, 30, bearing an indole moiety, has an IC50 of 25.3 nM for binding to the NAMPT protein and demonstrated promising inhibitory activities in the nanomolar range against several cancer cell lines (MCF-7 GI50 = 0.13 nM; MDA-MB-231 GI50 = 0.15 nM). Triple-negative breast cancer is the most malignant subtype of breast cancer with no effective targeted treatments currently available. Significant antitumor efficacy of compound 30 was achieved (TGI was 73.8%) in an orthotopic MDA-MB-231 triple-negative breast cancer xenograft tumor model. This paper reports promising lead molecules for the inhibition of NAMPT which could serve as a basis for further investigation.
