120384-18-1

Basic information

• Product Name: 4-Azidotetrafluorobenzaldehyde
• Synonyms: 4-Azidotetrafluorobenzaldehyde
• CAS NO: 120384-18-1
• Molecular Formula: C₇HF₄N₃O
• Molecular Weight: 219.0959528
• Product Categories: Aromatics, Miscellaneous Reagents
• Mol File: 120384-18-1.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Azidotetrafluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Azidotetrafluorobenzaldehyde(120384-18-1)
• EPA Substance Registry System: 4-Azidotetrafluorobenzaldehyde(120384-18-1)

Safety Data

• Hazardous Substances Data: 120384-18-1(Hazardous Substances Data)

Usage

Description

4-Azidotetrafluorobenzaldehyde is an organic compound characterized by its azide and tetrafluorophenyl groups. It is known for its reactivity and is commonly utilized in various chemical and material science applications due to its unique properties.

Uses

Used in Polymer Science:
4-Azidotetrafluorobenzaldehyde is used as a crosslinkable agent for the study of polymers. Its photoactivable group allows for the controlled formation of covalent bonds within polymer networks, which is crucial in understanding the structure-property relationships and the behavior of these materials under different conditions.
Used in Material Science:
In the field of material science, 4-Azidotetrafluorobenzaldehyde is employed as a key component in the synthesis of novel materials with tailored properties. Its ability to form crosslinks and its reactivity make it a valuable building block for the development of advanced materials with applications in various industries, such as electronics, aerospace, and biomedical engineering.
Used in Chemical Synthesis:
4-Azidotetrafluorobenzaldehyde is also used as a versatile intermediate in the synthesis of various organic compounds. Its unique functional groups enable the formation of a wide range of products, including pharmaceuticals, agrochemicals, and specialty chemicals, making it an important tool in the chemical industry.

Upstream product

• 653-37-2 perfluorobenzaldehyde 

Downstream Products

• 180293-27-0 4-azido-4-(bromomethyl)-2,3,5,6-tetrafluorobenzene 
• 126695-59-8 4-(hydroxymethyl)-2,3,5,6-tetrafluorophenyl azide 
• 1315501-27-9 C₁₃H₁₆F₄N₄ 
• 1315501-35-9 C₁₃H₁₆F₄N₄*ClH 
• 1315501-26-8 C₁₆H₁₉F₄N₃O₃ 
• 1315501-25-7 C₁₅H₁₇F₄N₃O₃ 
• 1315501-24-6 C₃₉H₆₅F₄N₄O₉P 
• 17078-34-1 4-(hydroxymethyl)-2,3,5,6-tetrafluoroaniline 

Relevant articles and documents

Microwave-assisted synthesis of substituted fluorophenyl mono- and diazides by SNAr. A fast methodology to prepare photoaffinity labeling and crosslinking reagents

The reaction of sodium azide with perfluorobenzene, containing an electron-withdrawing group, under microwave irradiation results in the fast preparation of p-substituted tetrafluorophenyl monoazides. Having an excess of sodium azide and a strong electron-withdrawing group like NO2 or CN, fluorophenyl diazides are also produced upon conventional or microwave heating. A synergic effect between the amount of sodium azide and the electron-withdrawing character of the substituents is observed giving different products. A discussion on the products and reaction mechanism is presented.

Synthesis of nitrophenyl and fluorophenyl azides and diazides by SNAr under phase-transfer or microwave irradiation: Fast and mild methodologies to prepare photoaffinity labeling, crosslinking, and click chemistry reagents

Two fast and mild methodologies to prepare nitrophenyl and fluorophenyl azides are presented. These aryl azides are extensively used as crosslinking, photoaffinity labeling, and click chemistry reagents. Substituted aryl azides are prepared by performing a SNAr substitution on halogenated benzenes with a phase-transfer catalyst (PTC) such as tetraethylammonium tetrafluoroborate (TEATFB), the reaction proceeds in several hours under rather mild temperatures (25°C to 70°C). Furthermore, aryl azides are also prepared within minutes under microwave irradiation at slightly higher temperatures (50°C to 70°C). These procedures could be applied in the preparation of other aryl azides. In the case of substituted pentafluoro benzene (pF), the type of products obtained in each reaction depends on the amount of sodium azide and the strength and position of electron-withdrawing substituents (COH, COR, COOR, CN, NO2, or F). A discussion on the mechanisms and the products obtained in these SNAr reactions is presented.

One-pot, two-step synthesis of unnatural α-amino acids involving the exhaustive aerobic oxidation of 1,2-diols

Herein, we report the nor-AZADO-catalyzed exhaustive aerobic oxidations of 1,2-diols to α-keto acids. Combining oxidation with transamination using dl-2-phenylglycine led to the synthesis of free α-amino acids (AAs) in one pot. This method enables the rapid and flexible preparation of a variety of valuable unnatural AAs, such as fluorescent AAs, photoactivatable AAs, and other functional AAs for bioorthogonal reactions.

STEPWISE ASSEMBLED CAPTURE COMPOUNDS COMPRISING A CLEAVABLE FUNCTION AND METHOD FOR ISOLATING AND/OR CHARACTERIZING BIOMOLECULES OR BIOMOLECULE FRAGMENTS, IN PARTICULAR PROTEINS OR PROTEIN FRAGMENTS, OF COMPLEX MIXTURES

The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound IC through the interaction of a c