1204332-46-6Relevant articles and documents
Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands
Da Ressurreica o, Ana Sofia M.,Vidu, Anamaria,Civera, Monica,Belvisi, Laura,Potenza, Donatella,Manzoni, Leonardo,Ongeri, Sandrine,Gennari, Cesare,Piarulli, Umberto
, p. 12184 - 12188 (2011/12/16)
A perfect fit: The nanomolar affinity of a diketopiperazine-derived cyclic RGD-peptidomimetic for the integrin αvβ 3 receptor can be attributed to its high structural pre-organization. The transdiketopiperazine scaffold induces an extended RGD disposition permitting all important interactions with the extracellular domain of the αvβ 3 integrin. The metal ion in the metaliondependent adhesion site region is represented by a magenta sphere.