1204589-80-9

Basic information

• Product Name: (S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine
• Synonyms: (S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine
• CAS NO: 1204589-80-9
• Molecular Weight: 218.342
• Mol File: 1204589-80-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine(1204589-80-9)
• EPA Substance Registry System: (S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine(1204589-80-9)

Safety Data

• Hazardous Substances Data: 1204589-80-9(Hazardous Substances Data)

Usage

General Description

(S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine is a chemical compound that falls under the category of substituted amphetamines. It is also known as (S)-PPPA and is a chiral compound with a molecular formula of C15H22N2. (S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine is a psychoactive substance that affects the central nervous system, primarily functioning as a stimulant and hallucinogen. It is often used recreationally for its euphoric and empathogenic effects, as well as its ability to enhance sensory perception and increase energy levels. However, it also poses significant health risks, including the potential for addiction, cardiovascular issues, and psychological disturbances. (S)-PPPA has been classified as a controlled substance in many countries due to its potential for abuse and harm.

Upstream product

• 102292-89-7 (2S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one 
• 126301-19-7 (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 63-91-2 L-phenylalanine 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 120125-43-1 (S)-tert-butyl (1-oxo-3-phenyl-1-(piperidin-1-yl)propan-2-yl)carbamate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 110-89-4 piperidine 

Downstream Products

• 1204589-74-1 (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(1-phenyl-3-(piperidin-1-yl)propan-2-yl)thiourea 
• 1454257-29-4 3-((S)-3-phenyl-1-(piperidin-1-yl)propan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione 

Relevant articles and documents

A new type of L-Tertiary leucine-derived ligand: Synthesis and application in Cu(II)-catalyzed asymmetric Henry reactions

A new series of Schiff bases derived from amino acids were developed as chiral ligands for Cu(II)-catalyzed asymmetric Henry reactions. The optimum ligand 7d exhibited outstanding catalytic efficiency in the Cu(II)-catalyzed asymmetric Henry additions of four nitroalkanes to different kinds of aldehydes to produce 76 desired adducts in high yields (up to 96%) with excellent enantioselectivities, up to 99% enantiomeric excess (ee).

Chiral primary amine catalyzed asymmetric direct cross-aldol reaction of acetaldehyde

The first primary aminocatalytic direct cross-aldol reaction of acetaldehyde is presented. Among the various vicinal diamines screened, the L-tert-leucine derivative 1c in conjunction with (H4SiW 12O40)0.25 was identified as the optimal catalyst; good catalytic activity (up to 99% yield in 4 h), and high enantioselectivities (up to 92% ee) were achieved for a range of donors, including aromatic aldehydes and isatin derivatives. Aqueous acetaldehyde solution and paraldehyde can be conveniently applied in this system.