1205548-00-0 Usage
Chemical Properties
Orange Brown Solid
Uses
4'-Dimethylamino 7,8-Dihydroxyflavone is a synthetic 7,8-Dihydroxyflavone derivative which promotes neurogenesis and exhibits potent antidepressant effect. The 7,8-dihydroxy groups are essential for the agonistic effect. 4'-Dimethylamino 7,8-Dihydroxyflavone displays higher TrkB agonistic activity than that of 7,8-Dihydroxyflavone (D452830).
Check Digit Verification of cas no
The CAS Registry Mumber 1205548-00-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,5,5,4 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1205548-00:
(9*1)+(8*2)+(7*0)+(6*5)+(5*5)+(4*4)+(3*8)+(2*0)+(1*0)=120
120 % 10 = 0
So 1205548-00-0 is a valid CAS Registry Number.
1205548-00-0Relevant articles and documents
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect
Liu, Xia,Chan, Chi-Bun,Jang, Sung-Wuk,Pradoldej, Sompol,Huang, Junjian,He, Kunyan,Phun, Lien H.,France, Stefan,Xiao, Ge,Jia, Yonghui,Luo, Hongbo R.,Ye, Keqiang
experimental part, p. 8274 - 8286 (2011/02/23)
7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. Our preliminary structural-activity relationship (SAR) study showed that the 7,8-dihydroxy groups are essential for the agonistic effect. To improv