1205553-66-7Relevant articles and documents
Catalytic asymmetric conjugate addition of nitroalkanes to 4-nitro5-styrylisoxazoles
Baschieri, Andrea,Bernardi, Luca,Ricci, Alfredo,Suresh, Surisetti,Adamo, Mauro F. A.
supporting information; scheme or table, p. 9342 - 9345 (2010/03/24)
(Chemical equation presented) Nitro versus nitro: 4-Nitro-5- styrylisoxazoles were used as masked α,β-unsaturated carboxylic acids in the titled catalytic asymmetric transformation. The 4-nitroisoxazole core acts as an activator of the conjugated alkene and a latent carboxylate functionality. The reaction proceeded with 5 mol% of a readily prepared phasetransfer catalyst at room temperature with remarkable diastereo- and enantioselectivity (see scheme).
