1207-90-5

Basic information

• Product Name: 2-Furanpropanenitrile, a-phenyl-
• CAS NO: 1207-90-5
• Molecular Formula: C13H11NO
• Molecular Weight: 197.236
• Mol File: 1207-90-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Furanpropanenitrile, a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furanpropanenitrile, a-phenyl-(1207-90-5)
• EPA Substance Registry System: 2-Furanpropanenitrile, a-phenyl-(1207-90-5)

Safety Data

• Hazardous Substances Data: 1207-90-5(Hazardous Substances Data)

Upstream product

• 42173-08-0 (Z)-3-(2-furyl)-2-phenylacrylonitrile 
• 617-88-9 2-Chloromethylfuran 
• 98-00-0 (2-furyl)methyl alcohol 
• 140-29-4 phenylacetonitrile 
• 1207-91-6 2-phenyl-3-(α-furyl)-propenenitrile 
• 98-01-1 furfural 

Relevant articles and documents

Base-controlled chemoselectivity: direct coupling of alcohols and acetonitriles to synthesise α-alkylated arylacetonitriles or acetamides

We achieved chemoselective synthesis of α-alkylated arylacetonitriles and acetamides by combining Ir complex-catalysed direct coupling of alcohols and nitriles by a simple adjustment of the base. Methanol and ethanol performed well as the alkylating reagents. This method of acetonitrile alkylation provided a novel approach for carbon chain extension.

Nickel-catalyzed hydrogen-borrowing strategy: Chemo-selective alkylation of nitriles with alcohols

The first nickel-catalyzed hydrogen-borrowing alkylation of a series of aryl acetonitriles with a variety of aryl, heteroaryl, allylic and alkyl alcohols releasing water as the by-product (>33 examples, up to 90% yield) is reported.

Sustainable Alkylation of Nitriles with Alcohols by Manganese Catalysis

A general and chemoselective catalytic alkylation of nitriles using a homogeneous nonprecious manganese catalyst is presented. This alkylation reaction uses naturally abundant alcohols and readily available nitriles as coupling partners. The reaction tolerates a wide range of functional groups and heterocyclic moieties, efficiently providing useful cyanoalkylated products with water as the only side product. Importantly, methanol can be used as a C1 source and the chemoselective C-methylation of nitriles is achieved. The mechanistic investigations support the multiple role of the metal-ligand manganese catalyst, the dehydrogenative activation of the alcohol, α-C-H activation of the nitrile, and hydrogenation of the in-situ-formed unsaturated intermediate.