1207290-13-8

Basic information

• Product Name: C₁₃H₁₃FO
• Synonyms: C₁₃H₁₃FO
• CAS NO: 1207290-13-8
• Molecular Weight: 204.244
• Mol File: 1207290-13-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₃FO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₃FO(1207290-13-8)
• EPA Substance Registry System: C₁₃H₁₃FO(1207290-13-8)

Safety Data

• Hazardous Substances Data: 1207290-13-8(Hazardous Substances Data)

Upstream product

• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 693-02-7 hex-1-yne 

Downstream Products

• 1256361-27-9 C₂₀H₂₁FN₂O₂S 
• 1453382-95-0 C₁₇H₂₂FN 
• 1207290-06-9 2-benzyl-3-butyl-6-fluoro-1-(2-methyl-1H-indol-3-yl)-1,2-dihydroisoquinoline 

Relevant articles and documents

N-Iodosuccinimide-Mediated Dimerization of 2-Alkynylnaphthols: A Highly Diastereoselective Construction of Bridged Polycyclic Compounds via Vinylidene ortho-Quinone Methide Intermediate

An unprecedented highly diastereoselective dimerization of 2-alkynylnaphthols is presented to furnish bridged polycyclic compounds containing a bicyclo[3.2.1]octane moiety with good to excellent yields. The reaction proceeded under mild conditions using N-iodosuccinimide as a promoter, simultaneously constructing one new C-O bond and two new C-C bonds. A tetra-substituted vinylidene ortho-quinone methide intermediate was likely involved, and the steric hindrance of substituents played a critical role in this transformation.

Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines

Iodonium compounds play a pivotal role in18F-fluorination of radiopharmaceuticals containing non-activated arenes. However, preparation of these species is limited to oxidation conditions or exchange with organometallics that are prepared from aryl halides. Herein we describe a novel “one-pot” process to assemble aryl(isoquinoline)iodonium salts in 40–94 % yields from mesoionic carbene silver complex and Aryl-I-Py2(OTf)2. The method is general, practical, and compatible with well-functionalized molecules as well as useful for the preparation of a wide range of18F-labeled isoquinolines resulting in up to 92 % radiochemical conversion. As proof of concept, a fluorinated isoquinoline alkaloid,18F-aspergillitine is prepared in 10 % isolated radiochemical yield from the corresponding phenyl(aspergillitine)iodonium salt.