120737-78-2

Basic information

• Product Name: 1-Boc-2-Methylpiperazine
• Synonyms: 2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(+/-)-1-N-BOC-2-METHYL PIPERAZINE;1-N-BOC-2-METHYLPIPERAZINE;TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;TERT-BUTYL-2-METHYL-1-PIPERAZINECARBOXYLATE;N-1-BOC-2-METHYLPIPERAZINE;N-4-BOC-3-METHYL-PIPERAZINE;4-N-Boc-3-methylpiperazine
• CAS NO: 120737-78-2
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: pharmacetical;Piperaizine
• Mol File: 120737-78-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 268.74 °C at 760 mmHg
• Flash Point: 116.33 °C
• Appearance: /
• Density: 0.997 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 8.49±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-2-Methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-2-Methylpiperazine(120737-78-2)
• EPA Substance Registry System: 1-Boc-2-Methylpiperazine(120737-78-2)

Safety Data

• RIDADR: 2735
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 120737-78-2(Hazardous Substances Data)

Usage

Uses

tert-Butyl 2-methylpiperazine-1-carboxylate is a useful reagent used in the synthesis of anthrafuran carboxamides with antitumor properties.

Upstream product

• 120737-77-1 tert-butyl 2-methyl-4-benzyl-1-piperazinecarboxylate 
• 3138-90-7 3-methyl-1-(phenylmethyl)piperazine 
• 128102-16-9 4-benzyl 1-tert-butyl 2-methylpiperazine-1,4-dicarboxylate 
• 109-07-9 (RS)-2-methylpiperazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1580440-27-2 tert-butyl 4-([1,1'-biphenyl]-3-yl)-2-methylpiperazine-1-carboxylate 
• 1207455-08-0 tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate 
• 945422-82-2 4-(2,4-dichloro-phenyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 945422-88-8 4-(2-chloro-4-fluoro-phenyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 120737-80-6 (1,1-dimethylethyl) 4-[4-[(4-fluorophenyl)(3-pyridinylcarbonyl)amino]butyl]-2-methyl-1-piperazinecarboxylate 

Relevant articles and documents

Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents

A persistent latent reservoir of virus in CD4+ T cells is a major barrier to cure HIV. Activating viral transcription in latently infected cells using small molecules is one strategy being explored to eliminate latency. We previously described the use of a FlpIn.FM HEK293 cellular assay to identify and then optimize the 2-acylaminothiazole class to exhibit modest activation of HIV gene expression. Here, we implement two strategies to further improve the activation of viral gene expression and physicochemical properties of this class. Firstly, we explored rigidification of the central oxy-carbon linker with a variety of saturated heterocycles, and secondly, investigated bioisosteric replacement of the 2-acylaminothiazole moiety. The optimization process afforded lead compounds (74 and 91) from the 2-piperazinyl thiazolyl urea and the imidazopyridine class. The lead compounds from each class demonstrate potent activation of HIV gene expression in the FlpIn.FM HEK293 cellular assay (both with LTR EC50s of 80 nM) and in the Jurkat Latency 10.6 cell model (LTR EC50 220 and 320 nM respectively), but consequently activate gene expression non-specifically in the FlpIn.FM HEK293 cellular assay (CMV EC50 70 and 270 nM respectively) manifesting in cellular cytotoxicity. The lead compounds have potential for further development as novel latency reversing agents.

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.

1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS

Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.