120747-41-3

Basic information

• Product Name: 9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL
• Synonyms: 9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL;9-TRIFLUOROMETHYL-9H-FLUOROEN-9-OL;9-TRIFLUOROMETHYLFLUORENE-9-OL
• CAS NO: 120747-41-3
• Molecular Formula: C14H9F3O
• Molecular Weight: 250.22
• Mol File: 120747-41-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 91°C
• Boiling Point: 348.8 °C at 760 mmHg
• Flash Point: 151.3 °C
• Appearance: /
• Density: 1.415 g/cm³
• Vapor Pressure: 1.85E-05mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL(120747-41-3)
• EPA Substance Registry System: 9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL(120747-41-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 120747-41-3(Hazardous Substances Data)

Usage

General Description

9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL is a chemical compound with the molecular formula C14H9F3O. It is a white to off-white solid that is used in various pharmaceutical and industrial applications. 9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL is a derivative of fluorene, which is a polycyclic aromatic hydrocarbon. The trifluoromethyl group attached to the fluorene ring imparts unique properties to the compound, making it useful in the synthesis of pharmaceuticals and other organic compounds. Additionally, the hydroxyl group present in the structure allows for potential interactions with other chemicals, making it valuable in various chemical processes. Overall, 9-TRIFLUOROMETHYL-9H-FLUOREN-9-OL is an important compound with diverse applications in the field of chemistry.

InChI:InChI=1/C14H9F3O/c15-14(16,17)13(18)11-7-3-1-5-9(11)10-6-2-4-8-12(10)13/h1-8,18H

Upstream product

• 486-25-9 9-fluorenone 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 75-46-7 trifluoromethan 
• 302912-29-4 1-([1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethan-1-one 
• 1400691-55-5 C₉H₁₆N₂*C₃H₂F₆O₂ 
• 2708-87-4 diethoxytrifluoromethylphosphonate 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 2803-00-1 N-trifluoroacetyl,N-benzyl piperazine 
• 2314-97-8 iodotrifluoromethane 
• 345959-36-6 1-(4-benzylpiperazin-1-yl)-2, 2, 2-trifluoroethanol 
• 75-63-8 Bromotrifluoromethane 

Downstream Products

• 159592-64-0 9-(Trifluoromethyl)fluorenyl tosylate 

Relevant articles and documents

Trifluoroacetophenone as nucleophilic trifluoromethylating reagent

Trifluoroacetophenone can be used as nucleophilic trifluoromethylating reagent towards non-enolizable ketones by action of potassium tert-butoxide.

Method for synthesizing 9-hydroxy -9-trifluoromethyl fluorene compounds

The method 9 - takes the substituted,phenyl trifluoroacetophenone compound shown in the formula (I) as a raw material 2 - in an organic solvent, at, under the action of a Lewis acid to obtain, hydroxyl - 9 trifluoromethylfluorene compound 25 °C -50 °C shown in formula 2-12 under the action of a Lewis acid . The reaction mixture, has the advantages of simple and easily, available raw materials (II) reaction, conditions, simple operation 9 - substrate universality. and the like under the action of a Lewis acid through, a post-treatment process. under the action of a Lewis acid.

METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS

PROBLEM TO BE SOLVED: To provide a method for producing trifluoromethyl group-containing alcohols useful as synthetic intermediates for medicines and agrochemicals. SOLUTION: This invention relates to a method for producing trifluoromethyl group-containing alcohols expressed by a formula (2), comprising: making carbonyl compounds expressed by a formula (1) react with trifluoromethane in an organic solvent in the presence of polyvalent ethers and potassium tert-butoxide, or kalium hexamethyldisilazide. (R1 and R2 are each independently a phenyl group etc.; R2 may combine with R1, to form a ring, and both R1 and R2 are not hydrogen atoms). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System

Fluoroform (HCF3, HFC-23) is a side product in the manufacture of polytetrafluoroethylene (Teflon). Despite its attractive properties, taming HCF3 for trifluoromethylation is quite problematic owing to its low acidity and the labilit