1207733-64-9

Basic information

• Product Name: C₂₀H₁₇BrN₄O
• CAS NO: 1207733-64-9
• Molecular Weight: 409.285
• Mol File: 1207733-64-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₇BrN₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₇BrN₄O(1207733-64-9)
• EPA Substance Registry System: C₂₀H₁₇BrN₄O(1207733-64-9)

Safety Data

• Hazardous Substances Data: 1207733-64-9(Hazardous Substances Data)

Upstream product

• 60-27-5 creatinine 
• 171734-73-9 1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde 

Relevant articles and documents

Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines

The synthesis of several novel substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones structurally related to aplysinopsin have been carried out under microwave irradiation and conventional heating methods. The analogs 3a, 3b, 3d-3g, 3k and 3l were evaluated for their in vitro cytotoxic activity against an NCI 60 human tumor cell line panel. Compound 3f exhibited good growth inhibitory properties against all but four of the human cancer cell lines examined, and afforded LC50 values a cytotoxic agent. Thus, the aplysinopsin analog 3f was regarded as a useful lead compound for further structural optimization.