1207969-02-5

Basic information

• Product Name: (4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone
• Synonyms: (4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone
• CAS NO: 1207969-02-5
• Molecular Weight: 369.138
• Mol File: 1207969-02-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone(1207969-02-5)
• EPA Substance Registry System: (4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone(1207969-02-5)

Safety Data

• Hazardous Substances Data: 1207969-02-5(Hazardous Substances Data)

Upstream product

• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 22532-61-2 2-bromo-6-hydroxybenzaldehyde 
• 2003-10-3 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone 

Downstream Products

• 1207969-03-6 4-bromo-2-[3-(trifluoromethyl)benzyl]-1-benzofuran 
• 1313197-56-6 3,5-dimethyl-N-[2-(1-methylethoxy)ethyl]-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313197-55-5 3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313197-54-4 N-(2-hydroxyethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313197-53-3 N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313196-53-0 3,5-dimethyl-1-[2-[3-(trifluoromethyl-)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxylic acid 
• 1313196-52-9 ethyl 3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxylate 
• 1207969-04-7 3-{2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl}benzoic acid 
• 1207963-60-7 N-(2-hydroxyethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl}benzamide 
• 1313196-27-8 ethyl 4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran 4-yl]-1,3-thiazole-5-carboxylate 
• 1207969-05-8 ethyl 3-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]benzoate 
• 1207969-15-0 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)benzyl]-1-benzofuran 

Relevant articles and documents

Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52

G-protein-coupled receptor 52 (GPR52) is an orphan Gs-coupled G-protein-coupled receptor. GPR52 inhibits dopamine D2 receptor signaling and activates dopamine D1/N-methyl-d-aspartate receptors via intracellular cAMP accumulation, and therefore, GPR52 agonists may have potential as a novel class of antipsychotics. A series of GPR52 agonists with a bicyclic core was designed to fix the conformation of the phenethyl ether moiety of compounds 2a and 2b. 3-[2-(3-Chloro-5-fluorobenzyl)-1-benzothiophen-7-yl]-N- (2-methoxyethyl)benzamide 7m showed potent activity (pEC50 = 7.53 ± 0.08) and good pharmacokinetic properties. Compound 7m significantly suppressed methamphetamine-induced hyperactivity in mice after oral administration of 3 mg/kg without disturbance of motor function.

AMIDE COMPOUND

A compound having GPR52 agonist activity or a salt thereof is provided. The compound can be provided as a preventive/therapeutic agent for schizophrenia or the like. The compound is represented by the following formula: wherein A represents —CONRa— or —NRaCO—, Ra represents a hydrogen atom or the like,B represents a hydrogen atom or the like,a ring Cy1 represents a six-membered aromatic ring which may have one or more substituents in addition to a group represented by -A-B,a ring Cy2 represents a six-membered ring which may be substituted with a halogen atom or the like,a ring Cy3 represents a five- or six-membered ring which may have one or more substituents;X represents C1-2 alkylene or the like,m represents an integer of 0 to 2, anda ring Cy4 represents a six-membered aromatic ring which may have one or more substituents.