120807-29-6Relevant articles and documents
Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents
Karypidou, Konstantina,Ribone, Sergio R.,Quevedo, Mario A.,Persoons, Leentje,Pannecouque, Christophe,Helsen, Christine,Claessens, Frank,Dehaen, Wim
, p. 3472 - 3476 (2018)
Synthesis and biological evaluation of a novel library of fused 1,2,3-triazole derivatives are described. The in-house developed multicomponent reaction based on commercially available starting materials was applied and broad biological screening against various viruses was performed, showing promising antiviral properties for compounds 14d, 14n, 14q, 18f and 18i against human coronavirus 229E. Further in silico studies identified the key molecular interactions between those compounds and the 3-chymotrypsin-like protease, which is essential to the intracellular replication of the virus, supporting the hypothesis that the protease is the target molecule of the potential antiviral derivatives.
An improved synthesis of N-aryl and N-heteroaryl substituted piperidones
Sch?n, Uwe,Messinger, Josef,Buckendahl,Prabhu,Konda
, p. 2519 - 2525 (2008/02/02)
An efficient Pd(0)-catalyzed protocol for the rapid and efficient preparation of N-aryl and N-heteroaryl substituted piperidones is described. The two step syntheses proceed with an overall yield of 50-70% using X-Phos as optimal ligand for the Pd(0)-cata
