1208233-13-9Relevant articles and documents
Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia
Verma, Kshitij,Zang, Tianzhu,Penning, Trevor M.,Trippier, Paul C.
, p. 3590 - 3616 (2019)
Aldo-keto reductase 1C3 (AKR1C3) catalyzes the synthesis of 9α,11β-prostaglandin (PG) F2α and PGF2α prostanoids that sustain the growth of myeloid precursors in the bone marrow. The enzyme is overexpressed in acute myeloid leukemia (
Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes
Tani, Hiroko,Hasumi, Keiko,Tatefuji, Tomoki,Hashimoto, Ken,Koshino, Hiroyuki,Takahashi, Shunya
experimental part, p. 151 - 157 (2010/04/06)
The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors. Crown Copyright