1209495-01-1

Basic information

• Product Name: rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate
• Synonyms: rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate
• CAS NO: 1209495-01-1
• Molecular Weight: 293.267
• Mol File: 1209495-01-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate(1209495-01-1)
• EPA Substance Registry System: rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate(1209495-01-1)

Safety Data

• Hazardous Substances Data: 1209495-01-1(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 121054-03-3 2-hydroxy-4-phenylbutanenitrile 

Downstream Products

• 1209495-12-4 4-phenyl-2-(thiophen-2-yl)butanenitrile 
• 1209495-13-5 4-phenyl-2-(thiophen-2-yl)butanenitrile 
• 1209495-10-2 (E)-2-phenethyl-4-phenylbut-3-enenitrile 
• 92615-42-4 2-(4-fluorophenyl)-4-phenylbutanenitrile 
• 1209495-08-8 4-phenyl-2-o-tolylbutanenitrile 
• 132769-57-4 4-phenyl-crotononitrile 
• 92615-41-3 3-Phenyl-1-<4-tolyl>-propylcyanid 
• 111026-47-2 2-(4-methoxyphenyl)-4-phenylbutanenitrile 
• 92615-43-5 2-(2-chlorophenyl)-4-phenylbutanenitrile 
• 1209495-09-9 2-(4-acetylphenyl)-4-phenylbutanenitrile 
• 1226495-17-5 2-fluoro-4-phenylbutanenitrile 
• 1403873-30-2 1-(1-cyano-3-phenylpropyl)pyridinium triflate 

Relevant articles and documents

Nickel-Catalyzed, Reductive C(sp3)?Si Cross-Coupling of α-Cyano Alkyl Electrophiles and Chlorosilanes

A nickel/zinc-catalyzed cross-electrophile coupling of alkyl electrophiles activated by an α-cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp3)?Si bond can be formed starting from two electrophilic reactants whereas previous methods rely on the combination of carbon nucleophiles and silicon electrophiles or vice versa.

Copper-Catalyzed Substitution of α-Triflyloxy Nitriles and Esters with Silicon Nucleophiles under Inversion of the Configuration

A copper-catalyzed nucleophilic displacement of α-triflyloxy nitriles and esters with silicon nucleophiles allows for the stereospecific generation of highly enantioenriched α-silylated carboxyl compounds. The enantioselective synthesis of α-silylated nitriles is unprecedented. The catalytic system exhibits good functional group tolerance. The stereochemical course of the substitution is shown to proceed with inversion of the configuration. The new reaction is an addition to the still limited number of methods for catalytic C(sp3)-Si cross-coupling.

Stereospecific suzuki cross-coupling of alkyl α-cyanohydrin triflates

-