120959-22-0

Basic information

• Product Name: N-(4-Ethoxyphenyl)-N'-[3-(3-piperidinomethylphenoxy)propyl]urea
• Synonyms: N-(4-Ethoxyphenyl)-N'-[3-(3-piperidinomethylphenoxy)propyl]urea
• CAS NO: 120959-22-0
• Molecular Weight: 411.544
• Mol File: 120959-22-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-Ethoxyphenyl)-N'-[3-(3-piperidinomethylphenoxy)propyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Ethoxyphenyl)-N'-[3-(3-piperidinomethylphenoxy)propyl]urea(120959-22-0)
• EPA Substance Registry System: N-(4-Ethoxyphenyl)-N'-[3-(3-piperidinomethylphenoxy)propyl]urea(120959-22-0)

Safety Data

• Hazardous Substances Data: 120959-22-0(Hazardous Substances Data)

Upstream product

• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 
• 5255-65-2 ethyl (4-ethoxyphenyl)carbamate 
• 156-43-4 4-Ethoxyaniline 

Relevant articles and documents

Synthesis and antiulcer activity of N-substituted N'-[3-[3- (piperidinomethyl)phenoxy]propyl]ureas: Histamine H2-receptor antagonists with a potent mucosal protective activity

As an aim toward developing new antiulcer agents, new N-substituted N'-[3- [3-(piperidinomethyl)phenoxy]propyl]ureas were synthesized and evaluated for histamine H2-receptor antagonistic, gastric antisecretory, and gastric mucosal protective activities. A QSAR study showed that the most favorable N- substituents were electron-donating straight-chain alkyl groups of short length such as ethyl group from the viewpoint of dual action, i.e., gastric antisecretory and mucosal protective actions. Among the ureas studied, compounds 4, 5, and 8-10 were selected as candidates for further study.