1210039-53-4Relevant articles and documents
Synthesis and pharmacological screening of some novel chalconyl derivatives of substituted phenyl semicarbazide
Singh, Hemendra Pratap,Pandeya,Chauhan,Sharma, Chandra Shekhar
experimental part, p. 74 - 80 (2012/02/04)
In the present study, we have synthesized chalcone and semicarbazide-linked chalonyl derivatives and the titled compounds confirmed by MS, IR, and 1H NMR techniques. The anticonvulsant activity was determined by maximal electroshock (MES) induced seizure method. A majority of the compounds exhibited significant anticonvulsant activity after intraperitoneal administration. The results show the importance of hydrogen bonding for activity. In the present study 5e, 5h, 5i, 6e, 6h, and 6i emerged as the most active molecules, showed significant anticonvulsant of activity. Springer Science+Business Media, LLC 2010.