121054-32-8

Basic information

• Product Name: Butanoic acid, 3-(benzoylamino)-, methyl ester, (3R)-
• CAS NO: 121054-32-8
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 121054-32-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 3-(benzoylamino)-, methyl ester, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-(benzoylamino)-, methyl ester, (3R)-(121054-32-8)
• EPA Substance Registry System: Butanoic acid, 3-(benzoylamino)-, methyl ester, (3R)-(121054-32-8)

Safety Data

• Hazardous Substances Data: 121054-32-8(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 139243-54-2 (R)-3-aminobutanoic acid methyl ester hydrochloride 
• 462118-58-7 2-(1-benzoylamino-2-tert-butylsulfanylcarbonyl-ethyl)-malonic acid dimethyl ester 
• 462118-69-0 3-benzoylamino-4-tert-butylsulfanylcarbonyl-butyric acid methyl ester 
• 14205-39-1 methyl 3-aminocrotonate 
• 69582-90-7 (Z)-methyl 3-(benzamido)but-2-enoate 
• 162921-81-5 (R)-3-Benzoylamino-pentanedioic acid monomethyl ester 
• 69582-90-7 methyl (E)-3-benzamido-3-butenoate 
• 1079306-45-8 (S)-methyl 3-benzamido-4-iodobutanoate 

Downstream Products

• 139243-54-2 (R)-3-aminobutanoic acid methyl ester hydrochloride 
• 121054-38-4 2(R)-methyl-3(R)-aminobutanoic acid N-benzoyl methyl ester 

Relevant articles and documents

Synthetic method of (R)-3- n-aminobutanol (by machine translation)

The invention belongs to, the field (R)- 3 - of pharmaceutical and chemical engineering, and particularly relates to a method for. preparing a product (R)- 3 - with good chemical purity, and optical, purity by, a, preparation method of a chiral drug midbody . (by machine translation)

A 3 (R) / (S)-amino-1-butanol method for the preparation of

The invention provides a method for preparing 3(R)/(S)-amidogen-1-butanol. The method comprises the steps that firstly, benzamide reacts with acetoacetic ester under the catalyzing action of p-toluenesulfonic acid, so that 3-benzamido-2-butene acid ester is generated; secondly, catalytic hydrogenation is conducted by using a chiral rhodium-diphosphine ligand compound as a catalyst for enantioselective hydrogenation, so that 3(R)/(S)-benzamide butyrate is generated highly selectively; thirdly, benzoyl is removed by means of mixed solvent of concentrated hydrochloric acid and alcohol, so that 3(R)/(S)-amino-crotonic acid ester hydrochloride is generated; finally, optically pure 3(R)/(S)-amidogen-1-butanol is obtained after ester carbonyl is reduced by means of hydronoron. According to the method, the raw materials are low in cost and easy to obtain, the technological operation is easy and convenient, resolution is not needed, the yield is high, cost is low, environmental friendliness is achieved, the optical purity of product is high, and the method is more suitable for industrial production.

Practical Rh(I)-catalyzed asymmetric hydrogenation of β-(acylamino) acrylates using a new unsymmetrical hybrid ferrocenylphosphine-phosphoramidite ligand: Crucial influence of an N-H proton in the ligand

(Chemical Equation Presented) Excellent enantioselectivities and high turnovers (S/C = 5000) were achieved in the Rh(I)-catalyzed asymmetric hydrogenation of both β-aryl-and β-alkyl-β-(acylamino)acrylates with a new unsymmetrical hybrid ferrocenylphosphine-phosphoramidite ligand, and the presence of an N-H proton in the ligand was demonstrated to have a crucial role in the enantioselectivity.