121099-13-6

Basic information

• Product Name: Cyclohexaneacetic acid, a-hydroxy-, methyl ester, (S)-
• CAS NO: 121099-13-6
• Molecular Formula: C9H16O3
• Molecular Weight: 172.224
• Mol File: 121099-13-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexaneacetic acid, a-hydroxy-, methyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexaneacetic acid, a-hydroxy-, methyl ester, (S)-(121099-13-6)
• EPA Substance Registry System: Cyclohexaneacetic acid, a-hydroxy-, methyl ester, (S)-(121099-13-6)

Safety Data

• Hazardous Substances Data: 121099-13-6(Hazardous Substances Data)

Upstream product

• 62783-63-5 cyclohexyl-oxo-acetic acid methyl ester 
• 143100-57-6 (S)-Cyclohexyl-(4-methoxy-phenoxy)-acetic acid 
• 139040-44-1 (R)-2,2,2-Trichloro-1-cyclohexyl-ethanol 
• 139040-39-4 1,1,1-trichloro(cyclohexyl)ethan-2-one 
• 67-56-1 methanol 
• 61475-31-8 (S)-hexahydromandelic acid 
• 74-88-4 methyl iodide 
• 143100-59-8 (S)-Cyclohexyl-(4-methoxy-phenoxy)-acetic acid methyl ester 
• 186581-53-3 diazomethane 

Downstream Products

• 300578-00-1 (S)-Cyclohexyl-((2R,3S)-3-phenylselanyl-tetrahydro-furan-2-yloxy)-acetic acid methyl ester 

Relevant articles and documents

Cationic BINAP-Ru(II) Halide Complexes: Highly Efficient Catalysts for Stereoselective Asymmetric Hydrogenation of α- and β-Functionalized Ketones

Cationic ruthenium-BINAP complexes 5, 7, and 10 of the formula Y, where X = Cl, Br, I; Y = Cl, Br, I, BF4, B(C6H5)4; arene = benzene, p-cymene, ethyl benzoate, and their enantiomers have been prepared by the reaction of arene-ruthenium halide complexes 4, 6, and 9 with (S)-BINAP or (R)-BINAP.Structures of the complexes were established by spectroscopy, conductivity, and a single-crystal X-ray analysis (5d: orthorhombic, P21212; a=20.141(2) Angstroem, b=18.504(1) Angstroem, c=12.241(1) Angstroem, V=4562.0(7) Angstroem3, Z=4, R=0.078 for unique 4177 reflections).BINAP derivatives with various substituents at the para and meta positions of four phenyl rings on phosphorus atoms and their cationic Ru(II) complexes have also been synthesized.These BINAP-Ru(II) complexes have been used as catalysts for the asymmetric hydrogenation of various unsaturated organic compounds such as α- and β-keto esters, allylic alcohols, and α,β-unsaturated carboxylic acids in excellent diastereo- and/or enantioselectivities.Catalytic activities and stereoselectivities depend highly on reaction conditions such as solvent, temperature, and additives.Variation of halogen ligands bound to ruthenium atom and substituents on four phenyl rings of BINAP also have exerted remarkable effects on the efficiency of the catalysis.Asymmetric hydrogenation of methyl (+/-)-2-(benzamidomethyl)-3-oxobutanoate catalyzed by the species derived from 9c and 3,5-(t-Bu)2-BINAP afforded the corresponding syn-(2S,3R)-17 in 98percent de and 99percent ee.

CsF-Promoted Esterification of Carboxylic Acids. A Practical Alternative to the Diazomethane Method and Direct Conversion of Organotin Carboxylates

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STEREOSELECTIVE REDUCTION OF C=X BY A CHIRAL 1,4-DIHYDROPYRIDINE (NADH-MIMIC) IN A SELF-IMMOLATIVE PROCESS

A series of prochiral ketones and a prochiral imine was reduced with high absolute stereoselectivity using an optically active 4-methyl-1,4-dihydropyridine in the presence of Mg(ClO4)2.