1211443-58-1

Basic information

• Product Name: 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid
• Synonyms: 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid;Ribociclib Intermediate 1
• CAS NO: 1211443-58-1
• Molecular Formula: C₁₂H₁₂ClN₃O₂
• Molecular Weight: 265.69558
• EINECS: 1592732-453-0
• Mol File: 1211443-58-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.61±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.63±0.30(Predicted)
• CAS DataBase Reference: 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid(1211443-58-1)
• EPA Substance Registry System: 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid(1211443-58-1)

Safety Data

• Hazardous Substances Data: 1211443-58-1(Hazardous Substances Data)

Usage

General Description

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid is a chemical compound that falls in the class of pyrrolopyrimidine derivatives. It is a potent inhibitor of kinases, which are enzymes that regulate various cellular processes. 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid has shown to have potential in the treatment of cancer and other diseases. Its unique structure and properties make it a promising candidate for the development of new drugs targeting specific pathways within cells. Further research and development of this compound may lead to the discovery of novel therapeutic agents for various medical conditions.

Downstream Products

• 1374639-75-4 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide succinate salt 
• 1374639-78-7 N,N‐dimethyl‐7‐cyclopentyl‐2‐{[5‐(4-tert-butoxycarbonylpiperazin‐1‐yl)pyridin‐2‐yl]amino}‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxamide 
• 1211443-61-6 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide 

Relevant articles and documents

Preparation method of 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d] pyrimidine-6-carboxylic acid

The invention relates to the technical field of medicine synthesis, particularly to a preparation method of 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d] pyrimidine-6-carboxylic acid. According to the method, 5-bromine-2-chloro-N-cyclopentylpyrimidine-4-amine is used as a main raw material, acrylic acid is used as a main auxiliary material, and a target product represented by a formula III is obtainedthrough nickel catalytic coupling, intramolecular cyclization and DDQ oxidative dehydrogenation. According to the preparation method, the use of a palladium catalyst is avoided, the raw materials arecheap and easy to obtain, the overall preparation cost is low, the yield is high, and the method is suitable for industrial production.

New intermediate of ribociclib, and synthetic method for preparing ribociclib by using new intermediate

The invention provides a new intermediate compound 6 of ribociclib, and a preparation method thereof, and a synthetic method for preparing ribociclib by using the new intermediate compound 6, whereinthe structure of the compound 6 is defined in the specif