1212160-10-5

Basic information

• Product Name: 5-(4-FLUORO-PHENYL)-3,4,4A,5,6,10B-HEXAHYDRO-2H-PYRANO[3,2-C]QUINOLINE
• Synonyms: TIMTEC-BB SBB012236;5-(4-FLUORO-PHENYL)-3,4,4A,5,6,10B-HEXAHYDRO-2H-PYRANO[3,2-C]QUINOLINE
• CAS NO: 1212160-10-5
• Molecular Formula: C18H18FNO
• Molecular Weight: 283.34
• Mol File: 1212160-10-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-FLUORO-PHENYL)-3,4,4A,5,6,10B-HEXAHYDRO-2H-PYRANO[3,2-C]QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUORO-PHENYL)-3,4,4A,5,6,10B-HEXAHYDRO-2H-PYRANO[3,2-C]QUINOLINE(1212160-10-5)
• EPA Substance Registry System: 5-(4-FLUORO-PHENYL)-3,4,4A,5,6,10B-HEXAHYDRO-2H-PYRANO[3,2-C]QUINOLINE(1212160-10-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1212160-10-5(Hazardous Substances Data)

Usage

Antibacterial agent

Synthetic broad-spectrum antibiotic

Mechanism of action

Inhibits topoisomerase II enzyme, leading to bacterial cell death

Spectrum of activity

Potent against Gram-positive and Gram-negative bacteria, as well as some atypical pathogens

Treatment of infections

Used for urinary tract infections, respiratory tract infections, and skin and soft tissue infections

Side effects

Potential for tendon rupture and central nervous system toxicity

Limited use

Due to side effects, its use has been restricted in recent years.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 459-57-4 4-fluorobenzaldehyde 
• 62-53-3 aniline 
• 142-68-7 TETRAHYDROPYRANE 
• 5676-81-3 4-fluorobenzalaniline 

Relevant articles and documents

Stereoselective synthesis of pyrano[3,2-c]- and furano[3,2-c]quinolines: Samarium diiodide-catalyzed one-pot aza-Diels-Alder reactions

Three-component aza-Diels-Alder reactions involving aromatic aldehydes, aromatic amines, and dihydropyran or dihydrofuran are effectively catalyzed by samarium diiodide to afford pyrano[3,2-c]- or furano[3,2-c]quinolines in good yields and with high stere

Ceric Ammonium Nitrate (CAN)-Catalyzed, Efficient, One-Pot, Three-Component, aza-Diels-Alder Reactions for a Facile Synthesis of Tetrahydropyranoquinoline Derivatives

A simple, efficient, and cost-effective method for the synthesis of tetrahydropyranoquinoline derivatives by a one-pot condensation of aromatic aldehyde, aromatic amine, and 3,4-dihydro-2H-pyran respectively in the presence of ceric ammonium nitrate (CAN)

Samarium triflate as mild and efficient catalyst for aza-diels-alder reaction: A facile synthesis of cis-fused pyrano-and furanoquinolines

Three-component coupling reactions of aldehydes, amines, and cyclic enol ethers have been carried out in the presence of samarium triflate to afford the corresponding pyrano and furanoquinolines in excellent yields with high endo-selectivity. The reaction