121409-45-8Relevant articles and documents
Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions
Ohkubo, Akihiro,Kuwayama, Yasukazu,Nishino, Yudai,Tsunoda, Hirosuke,Seio, Kohji,Sekine, Mitsuo
supporting information; scheme or table, p. 2496 - 2499 (2010/08/07)
Amidine-type protecting groups, i.e., N,N-dimethylformamidine (dmf) and N,N-dibutylformamidine (dbf) groups, introduced into nucleobases were rapidly removed under mild acidic conditions using imidazolium triflate (IMT) or 1-hydroxybenztriazole (HOBt). This new deprotection strategy allowed a 2′-O-methyl-RNA derivative bearing a base-labile group to be efficiently synthesized using a silyl-type linker. It was also found that our new method could be applied to the synthesis of an unmodified RNA oligomer.
(S,S)-(+)-pseudoephedrine as chiral auxiliary in asymmetric aza-Michael reactions. Unexpected selectivity change when manipulating the structure of the auxiliary
Etxebarria, Juan,Vicario, Jose L.,Badia, Dolores,Carrillo, Luisa,Ruiz, Nerea
, p. 8790 - 8800 (2007/10/03)
The asymmetric aza-Michael reaction of metal benzylamides to α,β-unsaturated amides derived from the chiral amino alcohol (S,S)-(+)-pseudoephedrine has been studied in detail. A deep study of the most important experimental parameters (solvent, temperatur
