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1214377-45-3

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1214377-45-3 Usage

Description

2-Chloro-6-(difluoromethoxy)pyridine is a pyridine derivative with the molecular formula C6H4ClF2NO. It features a chlorine atom at the 2-position and a difluoromethoxy group at the 6-position, making it a versatile intermediate in the synthesis of various chemical compounds.

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-(difluoromethoxy)pyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of complex and diverse chemical structures. Its presence in the molecule enhances the reactivity and functional group diversity, which is essential for creating new drug candidates.
Used in Agrochemical Industry:
In the agrochemical sector, 2-chloro-6-(difluoromethoxy)pyridine is utilized as an intermediate in the production of agrochemicals, where its unique structure and reactivity contribute to the creation of effective compounds for crop protection and other agricultural applications.
Used in Organic Synthesis:
2-Chloro-6-(difluoromethoxy)pyridine is employed as a valuable building block in organic synthesis due to its diverse functional groups and reactivity. It allows chemists to construct more complex molecules for various applications, including the development of new materials and compounds with specific properties.

Check Digit Verification of cas no

The CAS Registry Mumber 1214377-45-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,4,3,7 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1214377-45:
(9*1)+(8*2)+(7*1)+(6*4)+(5*3)+(4*7)+(3*7)+(2*4)+(1*5)=133
133 % 10 = 3
So 1214377-45-3 is a valid CAS Registry Number.

1214377-45-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-6-(difluoromethoxy)pyridine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1214377-45-3 SDS

1214377-45-3Downstream Products

1214377-45-3Relevant articles and documents

Fluorine in drug design: A case study with fluoroanisoles

Xing, Li,Blakemore, David C.,Narayanan, Arjun,Unwalla, Ray,Lovering, Frank,Denny, R. Aldrin,Zhou, Huanyu,Bunnage, Mark E.

, p. 715 - 726 (2015)

Anisole and fluoroanisoles display distinct conformational preferences, as evident from a survey of their crystal structures. In addition to altering the free ligand conformation, various degrees of fluorination have a strong impact on physicochemical and pharmacokinetic properties. Analysis of anisole and fluoroanisole matched molecular pairs in the Pfizer corporate database reveals interesting trends: 1) PhOCF3 increases log D by ~1 log unit over PhOCH3 compounds; 2) PhOCF3 shows lower passive permeability despite its higher lipophilicity; and 3) PhOCF3 does not appreciably improve metabolic stability over PhOCH3. Emerging from the investigation, difluoroanisole (PhOCF2H) strikes a better balance of properties with noticeable advantages of log D and transcellular permeability over PhOCF3. Synthetic assessment illustrates that the routes to access difluoroanisoles are often more straightforward than those for trifluoroanisoles. Whereas replacing PhOCH3 with PhOCF3 is a common tactic to optimize ADME properties, our analysis suggests PhOCF2H may be a more attractive alternative, and greater exploitation of this motif is recommended.

Tri- and difluoromethoxylated N-based heterocycles ? Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

Landelle, Gregory,Schmitt, Etienne,Panossian, Armen,Vors, Jean-Pierre,Pazenok, Sergiy,Jeschke, Peter,Gutbrod, Oliver,Leroux, Frédéric R.

, p. 155 - 165 (2017/09/07)

The preparation of F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid and the evaluation of their biological activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate. To allow a facile access to the second F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also ?pyrazoles, ?pyrazine, ?pyridazine, and ?quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities.

TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS

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Page/Page column 106, (2012/09/11)

The present invention provides a compound of formula (I): as further described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds.

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