1215118-20-9

Basic information

• Product Name: 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid
• Synonyms: 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid
• CAS NO: 1215118-20-9
• Molecular Weight: 404.466
• Mol File: 1215118-20-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid(1215118-20-9)
• EPA Substance Registry System: 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid(1215118-20-9)

Safety Data

• Hazardous Substances Data: 1215118-20-9(Hazardous Substances Data)

Upstream product

• 37033-95-7 5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester 
• 3418-69-7 7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one 
• 1215118-67-4 tert-butyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215118-69-6 tert-butyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215119-77-9 tert-butyl 2-(7-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate 
• 1215119-78-0 tert-butyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate 
• 1215118-68-5 tert-butyl 2-(7-hydroxy-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215118-65-2 tert-butyl 2-(7-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1174512-53-8 7-bromo-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one 
• 16732-70-0 ethyl 5-bromoindolecarboxylate 

Downstream Products

• 1215119-30-4 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid 
• 1215119-31-5 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid 

Relevant articles and documents

(7-Benzyloxy-2,3-dihydro- 1H -pyrrolo[1,2-a]indol-1-yl)acetic acids as S1P1 functional antagonists

S1P1 is a validated target for treatment of autoimmune disease, and functional antagonists with superior safety and pharmacokinetic properties are being sought as second generation therapeutics. We describe the discovery and optimization of (7-benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acids as potent, centrally available, direct acting S1P1 functional antagonists, with favorable pharmacokinetic and safety properties.