1215212-35-3

Basic information

• Product Name: 2-(3,5-difluorophenyl)thiophene
• Synonyms: 2-(3,5-difluorophenyl)thiophene
• CAS NO: 1215212-35-3
• Molecular Weight: 196.22
• Mol File: 1215212-35-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,5-difluorophenyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-difluorophenyl)thiophene(1215212-35-3)
• EPA Substance Registry System: 2-(3,5-difluorophenyl)thiophene(1215212-35-3)

Safety Data

• Hazardous Substances Data: 1215212-35-3(Hazardous Substances Data)

Upstream product

• 17984-89-3 triethoxy(thiophen-2-yl)silane 
• 2265-91-0 1,3-difluoro-5-iodobenzene 
• 1003-09-4 2-bromothiophene 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 188290-36-0 thiophene 

Downstream Products

• 1365721-98-7 5-(3,5-difluorophenyl)thiophene-2-sulfonyl chloride 
• 1365721-30-7 2-({[5-(3,5-difluorophenyl)thiophen-2-yl]sulfonyl}amino)-5-methyl-1,3-thiazole-4-carboxylic acid 

Relevant articles and documents

Manganese(III) acetate-mediated synthesis of biaryls under microwave irradiation

Manganese(III) acetate (Mn(OAc)3)-mediated synthesis of biaryls and heterobiaryls starting from arylboronic acid was developed under microwave irradiation in high yields. Microwaves were also used for the synthesis of Mn(OAc)3 from KMnO4 and acetic acid. Additional irradiation of this in situ generated Mn(OAc)3 with arylboronic acids, which in turn furnished the biaryls in high yields in a one pot reaction. This is superior from the point of view of yield, short reaction time, sensitive functional group toleration, and more environmentally friendly than the reported methods with a minimum amount of benzene and thiophene as a reagent but not as a solvent.

NEW COMPOUNDS

A compound of formula (I), wherein A is S, O or a double bond, and L is a substituted thiazolyl, phenyl or pyridyl. The compound is useful for the treatment of inflammation and cancer.